Publications by authors named "Rosemarie Ford"
Article Synopsis
- Natural killer (NK) cell subsets with adaptive properties play a significant role in enhancing vaccine-induced immune responses, particularly against SARS-CoV-2, and exhibit specialization in antibody-dependent functions.
- In people living with HIV (PLWH), SARS-CoV-2 infection leads to a change in NK cell characteristics, resulting in a more differentiated/adaptive phenotype, which is also observed after vaccination.
- The study highlights that adaptive NK cells not only contribute to sustained immune responses post-infection but can also enhance the effectiveness of vaccines, suggesting their potential to support immune protection in vulnerable populations like PLWH.
Patients with haematological malignancies are more likely to have poor responses to vaccination. Here we provide detailed analysis of the humoral and cellular responses to COVID-19 vaccination in 69 patients with B-cell malignancies. Measurement of anti-spike IgG in serum demonstrated a low seroconversion rate with 27.
View Article and Find Full Text PDFWe assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls. We also observed a delayed development of neutralization in PLWH that was underpinned by a reduced frequency of spike-specific memory B cells (MBCs).
View Article and Find Full Text PDFPeople living with HIV (PLWH) on suppressive antiretroviral therapy (ART) can have residual immune dysfunction and often display poorer responses to vaccination. We assessed in a cohort of PLWH (n=110) and HIV negative controls (n=64) the humoral and spike-specific B-cell responses following 1, 2 or 3 SARS-CoV-2 vaccine doses. PLWH had significantly lower neutralizing antibody (nAb) titers than HIV-negative controls at all studied timepoints.
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