Hydroethanolic Extracts of and Reduced Parasitemia in Balb/c Mice.

Malaria is one of the most important infectious diseases in Africa especially in Cameroon. The nonaccessibility to current treatments for poor people and the appearance of drug-resistant parasites stimulate the search for alternative treatments. The aim of this study was to evaluate the antimalarial activity and the safety of hydroethanolic extracts from and .

Potential of a Khaya ivorensis -Alstonia boonei extract combination as antimalarial prophylactic remedy.

Ethnopharmacological Relevance: The decoction of the combined stem barks of Khaya ivorensis A. Chev. (Meliaceae) and Alstonia boonei De Wild (Apocynaceae) has a history of use in traditional medicine of central Cameroon for malaria treatment but also for the prevention of the disease.

Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon.

Aim Of The Study: In a search for new plant-derived biologically active compounds against malaria parasites, we have carried out an ethnopharmacological study to evaluate the susceptibility of cultured Plasmodium falciparum to extracts and fractions from seven Cameroonian medicinal plants used in malaria treatment. We have also explored the inhibition of the Plasmodium falciparum cysteine protease Falcipain-2.

Materials And Methods: Plant materials were extracted by maceration in organic solvents, and subsequently partitioned or fractionated to afford test fractions.