Publications by authors named "Rosella Melchiotti"
J Clin Invest
August 2018
Article Synopsis
- - In type 1 diabetes, CD8+ T cells that target insulin-producing β cells in the pancreas are involved in the destruction of these cells, but the role of similar T cells found in the blood is not well understood.
- - A study tracked different circulating β cell-reactive CD8+ T cell subsets and β cell function for 2 years post-diagnosis, finding a positive correlation between certain T cells (CD57+ memory T cells) and insulin levels in kids under 12.
- - The research suggests that changes in these specific T cells can reflect the body's ability to produce insulin, indicating their potential use for monitoring the immune response and as a target for future treatments in type 1 diabetes.
