Publications by authors named "Roselinde van Os"
Controlled ovarian hyperstimulation (COH) used in IVF produces lower implantation rates per embryo transferred compared to natural cycles utilized in ovum donation, suggesting a suboptimal endometrial development. Endometrial receptivity has recently been investigated in natural menstrual cycles with the aid of microarray technology. The aim of this study is to investigate the impact of COH using urinary gonadotrophins with a long protocol with GnRH agonists without progesterone supplementation (similar to the natural cycle) on endometrial gene expression profiles during the window of implantation by comparing the profiles at day hCG + 7 of COH versus LH + 7 of a previous natural cycle in the same women.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how the embryo interacts with the endometrium during the implantation process by comparing gene expression in different phases of the menstrual cycle.
- Researchers analyzed tissue samples from the same fertile woman at two points (LH+2 and LH+7) and identified 211 genes whose expression significantly changed, unveiling both known and novel genes related to endometrial receptivity.
- The study's validation showed that specific genes, like GPx-3, claudin-4, and SLC1A1, exhibit unique patterns of expression during the menstrual cycle, emphasizing the intricate mechanisms involved in preparing the endometrium for implantation.