Publications by authors named "Roselaine Campos Targino"
Article Synopsis
- Tetanus toxin (TeNT) is created by a widespread spore-forming bacillus, and although there's a safe vaccine, tetanus remains common in low-income countries due to insufficient booster shots and varying vaccine responses.* -
- Researchers identified a set of monoclonal antibodies (mAbs) that can neutralize TeNT by preventing its binding to neurons and showed that a combination of three specific mAbs can protect mice from the toxin's effects.* -
- They developed stable cell lines to produce large quantities of these mAbs and conducted various tests (like ELISA and surface plasmon resonance) to confirm the antibodies' effectiveness in binding to TeNT and inhibiting its activity.*
Tumor necrosis factor alpha (TNFα) is a pro-inflammatory cytokine that mediates the homeostasis of immune responses; its exacerbated production is associated with the pathogenesis of autoimmune and chronic inflammatory diseases. Anti-TNFα drugs have revolutionized the treatment of inflammatory conditions such as rheumatoid arthritis and Crohn's disease. Currently, a worldwide race is on stage for the production of biosimilars moved by patent expiration of monoclonal antibodies (mAbs), such as anti-TNFα adalimumab.
View Article and Find Full Text PDFEarly and accurate detection of primary or metastatic tumors is of great value in staging, treatment management, and prognosis. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of solid cancers, and so, is a promising approach for tumor imaging. The GX1 (CGNSNPKSC) peptide was identified by phage display library and has been investigated as a marker for human cancers.
View Article and Find Full Text PDFBackground And Objective: Radiotracer diagnosis of insulinoma, can be done using somatostatin or glucagon-like peptide 1 (GLP-1). Performance of GLP-1 antagonists tends to be better than of agonists.
Methods: We investigated the uptake of the antagonist exendin (9-39), radiolabeled with technetium- 99m.
Gliomas are the most common type among all central nervous system tumors. The aggressiveness of gliomas is correlated with the level of angiogenesis and is often associated with prognosis. The aim of this study is to evaluate the novel GX1 peptide and the heterodimer RGD-GX1 radiolabeled with technetium-99m, for angiogenesis detection in glioma models.
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