Role of the Fc region in CD70-specific antibody effects on cardiac transplant survival.

Background: The role of the CD70-specific antibody and the mechanisms by which it extends transplant survival are not known.

Methods: Fully major histocompatibility complex-mismatched heterotopic heart transplantation (BALB/c to C57BL/6) was performed. Treated mice received intraperitoneal injections of wild-type (WT) CD70-specific antibody (FR70) or IgG1 or IgG2a chimeric antibodies on days 0, 2, 4, and 6 posttransplantation.