Publications by authors named "Roseann Waterhouse"
Safety, Tolerability, and Pharmacodynamics of the ADAMTS-5 Nanobody M6495: Two Phase 1, Single-Center, Double-Blind, Randomized, Placebo-Controlled Studies in Healthy Subjects and Patients With Osteoarthritis.
ACR Open Rheumatol
April 2024
Article Synopsis
- The study aimed to evaluate the safety, pharmacokinetics (how the drug moves through the body), and pharmacodynamics (the effects of the drug) of M6495, a new medication, in healthy volunteers and osteoarthritis patients.
- Two randomized, placebo-controlled studies were conducted: one with healthy men and another with osteoarthritis patients, assessing various doses and administration methods of M6495 over a period of 106 days.
- Results showed that M6495 was well tolerated with minimal adverse effects and significantly reduced biomarkers associated with osteoarthritis, indicating its potential as a disease-modifying treatment.
Problem: Murine pregnancy-specific glycoproteins (PSGs) are encoded by 17 different genes. Different family members have different expression levels at different stages of embryonic development. It is currently unknown whether all members of this family of placentally secreted proteins have the same function and bind to the same receptor.
View Article and Find Full Text PDFPregnancy-specific glycoproteins (PSGs) are a family of secreted proteins produced by the placenta, which are believed to have a critical role in pregnancy success. Treatment of monocytes with three members of the human PSGs induces interleukin (IL)-10, IL-6, and transforming growth factor-beta(1) (TGF-beta(1)) secretion. To determine whether human and murine PSGs have similar functions and use the same receptor, we treated wild-type and CD9-deficient macrophages with murine PSG17N and human PSG1 and -11.
View Article and Find Full Text PDFPregnancy-specific glycoproteins (PSGs) are a family of highly similar secreted proteins produced by the placenta. PSG homologs have been identified in primates and rodents. Members of the human and murine PSG family induce secretion of antiinflammatory cytokines in mononuclear phagocytes.
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