Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity.

Purpose: The aim of this study is to evaluate the relationship between the CYP450 enzyme family and cisplatin toxicity.

Methods: This article examined a collection of studies suggesting that CYP450 enzymes may influence cisplatin toxicity. We performed a narrative mini-review.

Coffee consumption, obesity and type 2 diabetes: a mini-review.

Purpose: The effects of regular coffee intake on weight gain and development of diabetes are reviewed. The pathophysiology of obesity and type 2 diabetes as well as the necessity of preventive options based on the increasing prevalence of these two disorders worldwide is briefly discussed. The relationship between weight gain and development of diabetes is also presented.