Publications by authors named "Rose Said"
Article Synopsis
- Vascular smooth muscle cell (VSMC) activity is crucial in atherothrombotic diseases, and the study investigates how mechanical stretch affects thrombin generation in these cells.
- Mechanical stretch at higher levels (10% cyclic stretch) increases thrombin generation and integrin α(v)β(3) expression, while static stretch does not have this effect.
- The findings indicate that this increase is linked to integrin signaling pathways and suggests that thrombin generated by cyclic stretch might play a role in the remodeling of blood vessels.
Background: Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB.
Methods: We used Calibrated Automated Thrombography to assess blood coagulation of 10 low-risk patients operated for valve replacement with CPB, under 2 experimental conditions, one implicating platelets as platelet dysfunction has been described to occur during CPB.