Publications by authors named "Rose O Tompkins"
Article Synopsis
- ACHD patients have a higher likelihood of rejection after heart transplantation compared to non-ACHD patients, with 21% experiencing cellular rejection and 15.8% antibody-mediated rejection.
- Despite this, there was no significant increase in hospital readmissions or allograft vasculopathy one year post-transplant.
- Overall, with careful patient selection and management, heart transplantation can be a viable option for adults with congenital heart disease.
Background: Adults with congenital heart disease (CHD) have been considered potentially high risk for novel coronavirus disease-19 (COVID-19) mortality or other complications.
Objectives: This study sought to define the impact of COVID-19 in adults with CHD and to identify risk factors associated with adverse outcomes.
Methods: Adults (age 18 years or older) with CHD and with confirmed or clinically suspected COVID-19 were included from CHD centers worldwide.
During development, the ventricular conduction system (VCS) arises from the trabecular or spongy myocardium. VCS and trabecular myocytes proliferate at a significantly slower rate than compact zone myocardial cells, establishing a transmural cell cycle gradient. The molecular determinants of VCS/trabecular myocyte cell cycle arrest are not known.
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