Publications by authors named "Rosario Zeppa"
Article Synopsis
- * Standard treatments include palliative chemotherapy and radiotherapy, with platinum-based doublets combined with third-generation agents as the first-line therapy; histology plays a key role in treatment decisions.
- * Advances in targeted therapies have identified key molecular targets like VEGF and EGFR, leading to the development of treatments such as bevacizumab and gefitinib that have shown improved survival rates in certain patient populations.
Non-small-cell lung cancer (NSCLC) is not considered to be immunogenic, but it may provide an accessible target for the properly primed immune system. Identifying lung tumor antigens and presenting them in the optimal context may enable the immune system to generate anti-lung tumor effector cells, which are usually absent. Despite encouraging preclinical and Phase I-II data, no specific active cancer vaccine has been approved for NSCLC therapy to date.
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- Lung cancer remains the top cause of cancer-related deaths globally, particularly affecting older adults who are increasingly being considered for chemotherapy.
- Assessing elderly patients’ overall health through a comprehensive geriatric assessment is crucial to determine the best chemotherapy approach since some can handle it well while others may need adjustments due to severe side effects.
- There is a lack of focused clinical trials for older patients with advanced non-small cell lung cancer (NSCLC), and future research should prioritize including evaluations of functional status and comorbidities for better treatment outcomes.
Lung cancer is the most common cancer in the world. One third of patients with non-small cell lung cancer (NSCLC) are diagnosed with locally or regionally advanced unresectable disease at presentation. Currently, in this stage of disease, a combination of chemotherapy and radiotherapy is the standard treatment approach for patients with good performance status, and concomitant chemo-radiotherapy has demonstrated to be the best therapeutic approach.
View Article and Find Full Text PDFThe expression of the anti-apoptotic protein BAG3 is induced in several cell types by exposure to high temperature, oxidants, and other stressful agents. We investigated whether exposure to 50 Hz electromagnetic fields raised BAG3 levels in the human melanoma cell line M14, in vitro and in orthotopic xenografts. Exposure of cultured cells or xenografts for 6 h or 4 weeks, respectively, produced a significant (P < 0.
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- Pemetrexed is a chemotherapy drug that has improved treatment options for advanced non-small cell lung cancer (NSCLC), leading to a need for ongoing research into safe and effective therapies.
- The review discusses how pemetrexed works, its safety, and effectiveness in treating NSCLC at different stages, emphasizing the importance of matching treatment to specific cancer types.
- Experts believe that using pemetrexed in combination with cisplatin for advanced non-squamous NSCLC has greatly advanced treatment methods and is safer than previous cisplatin-based therapies.