Publications by authors named "Rosario Nicola Brancaccio"
The nasopharyngeal tract contains a complex microbial community essential to maintaining host homeostasis. Recent studies have shown that SARS-CoV-2 infection changes the microbial composition of the nasopharynx. Still, little is known about how it affects the fungal microbiome, which could provide valuable insights into disease pathogenesis.
View Article and Find Full Text PDFSeveral studies reported the presence of a recently discovered polyomavirus (PyV), Lyon IARC PyV (LIPyV), in human and domestic animal specimens. LIPyV has some structural similarities to well-established animal and human oncogenic PyVs, such as raccoon PyV and Merkel cell PyV (MCPyV), respectively. In this study, we demonstrate that LIPyV early proteins immortalize human foreskin keratinocytes.
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- The study investigates how HIV interacts with various viruses to influence the development of conjunctival squamous cell carcinoma (SCC) by analyzing conjunctiva samples from both HIV-positive and negative individuals.
- Among the viruses studied, beta human papillomavirus (HPV) and Epstein-Barr virus (EBV) were found to significantly increase the risk of neoplasia, particularly in HIV-positive patients.
- Next-generation sequencing identified potential new HPV types, indicating that further research on how these viruses affect tumor tissue is necessary to establish a causal link.
Actinic keratosis (AK) arises on photo-damaged skin and is considered to be the precursor lesion of cutaneous squamous cell carcinoma (cSCC). Many findings support the involvement of β human papillomaviruses (HPVs) in cSCC, while very little is known on γ HPV types. The objective of this study was to characterize the spectrum of PV types in healthy skin (HS) and AK samples of the same immunocompetent individuals using next generation sequencing (NGS).
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