Publications by authors named "Rosario Luquin Piudo"
Article Synopsis
- Parkinson's disease (PD) is the second most common neurodegenerative disease in older adults, prompting the need for accurate animal models to study its causes and test new treatments.
- Researchers tested canine adenovirus type 2 (CAV-2) vectors in a monkey species that naturally develops neurodegenerative issues and found that these vectors led to long-lasting, neuron-specific gene expression without triggering a significant immune response.
- By introducing a specific mutation related to PD within the vectors, the study observed that these modified vectors caused motor symptoms and brain changes resembling Parkinson's within four months.
