Long-Term Air Pollution Exposure and Amyotrophic Lateral Sclerosis in Netherlands: A Population-based Case-control Study.

Background: Recently, there has been increasing evidence that exposure to air pollution is linked to neurodegenerative diseases, but little is known about the association with amyotrophic lateral sclerosis (ALS).

Objectives: We investigated the association between long-term exposure to air pollution and risk of developing ALS.

Methods: A population-based case-control study was conducted in Netherlands from 1 January 2006 to 1 January 2013.