Publications by authors named "Rosanne W Koutstaal"
Article Synopsis
- Puumala orthohantavirus (PUUV) can cause hemorrhagic fever with renal syndrome primarily through infection of endothelial cells, leading to increased vascular permeability.
- Traditional studies used static 2D cultures of endothelial cells, which do not accurately mimic the body's environment, prompting the need for better models.
- The new 3D vessels-on-chip model allows for a more realistic study of endothelial responses to PUUV, showing that infection increases monocyte adhesion instead of vascular permeability, and can potentially aid in researching treatments for similar viruses.
