Publications by authors named "Rosanne Koutstaal"
Article Synopsis
- Puumala orthohantavirus (PUUV) can cause hemorrhagic fever with renal syndrome primarily through infection of endothelial cells, leading to increased vascular permeability.
- Traditional studies used static 2D cultures of endothelial cells, which do not accurately mimic the body's environment, prompting the need for better models.
- The new 3D vessels-on-chip model allows for a more realistic study of endothelial responses to PUUV, showing that infection increases monocyte adhesion instead of vascular permeability, and can potentially aid in researching treatments for similar viruses.
Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies is to recognize overexpressed or specific tumor antigens and initiate either direct F(ab')-mediated tumor cell killing, or Fc-mediated effects such as complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity/phagocytosis (ADCC/P) after binding to activating Fc receptors. All antibodies used in the clinic are of the IgG isotype.
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