Publications by authors named "Rosanna K Jackson"
DNA-dependent protein kinase (DNA-PK) plays a key role in repair of radiation-induced DNA double strand breaks (DSB) by non-homologous end-joining. DNA-PK inhibitors (DNA-PKi) are therefore efficient radiosensitisers, but normal tissue radiosensitisation represents a risk for their use in radiation oncology. Here we describe a novel prodrug, SN38023, that is metabolised to a potent DNA-PKi (IC87361) selectively in radioresistant hypoxic cells.
View Article and Find Full Text PDFArticle Synopsis
- The UKALL 2011 trial evaluated the effects of different dosing regimens of dexamethasone in treating acute lymphoblastic leukaemia, focusing on a short (10 mg/m/d for 14 days) versus a standard (6 mg/m/d for 28 days) approach to see which would be more effective and have fewer toxicities.
- Blood samples from 174 children were analyzed to study how dexamethasone levels varied, finding significant differences in drug exposure amongst patients and a higher cumulative exposure with the longer dosing regimen.
- The findings suggest that the duration of dexamethasone therapy and the overall drug exposure may have a greater impact on treatment response than the actual dose taken, with no
Article Synopsis
- * Combining selumetinib with the steroid dexamethasone enhances cell death through the proapoptotic protein BIM, demonstrating strong synergism in preclinical models.
- * Ongoing research, including the Seludex trial, is evaluating this combination in children with hard-to-treat acute lymphoblastic leukemia, showing promising results in reducing leukemia burden in mice.
Dexamethasone is a key component in the treatment of childhood acute lymphoblastic leukaemia (ALL). Despite playing a key role in the improved survival of ALL over several decades, intensification of dexamethasone therapy has also contributed to the increased toxicity associated with treatment, which is now seen to be at unacceptable levels given the favourable disease prognosis. Therefore the focus for treatment is now shifting towards reducing toxicity whilst maintaining current survival rates.
View Article and Find Full Text PDFMedial prefrontal cortex (mPFC) and orbitofrontal cortex (OFC) play critical roles in cognition and behavioural control. Glutamatergic, GABAergic, and monoaminergic dysfunction in the prefrontal cortex has been hypothesised to underlie symptoms in neuropsychiatric disorders. Here we characterised electrically-evoked field potentials in the mPFC and OFC.
View Article and Find Full Text PDF