Publications by authors named "Rosangela R Rea"
Objectives: To evaluate a postpartum telephone-based lifestyle intervention to prevent diabetes in high-risk women with recent gestational diabetes mellitus (GDM).
Design: Multicentre parallel randomised clinical trial.
Setting: Specialised antenatal clinics in the Brazilian National System.
Article Synopsis
- The TOP1 study examined the effects of switching from twice-daily basal insulin to once-daily insulin glargine (Gla-300) in adults with type 1 diabetes (T1D), focusing on glycemic control and quality of life over 28 weeks.
- Despite no significant change in HbA1c levels after switching insulin regimens, participants experienced meaningful reductions in fasting blood glucose and improved overall glycemic profiles.
- Patients also reported a significant increase in treatment satisfaction and a decrease in hypoglycemic events, indicating a positive impact on their diabetes management and quality of life.
Article Synopsis
- * A study in Brazil analyzed data from adult patients who had serum creatinine tests from June 2018 to May 2021 and found that 42% of those tests did not include urinary albumin-to-creatinine ratio assessments, which are important for evaluating kidney health.
- * The results showed that non-nephrologists were the main requesters of kidney function tests, indicating a need for better adherence to guidelines and promoting teamwork among healthcare professionals to enhance CKD management.
Background: Dysglycemias have been associated with worse prognosis in critically ill patients with COVID-19, but data on the association of dysglycemia with COVID-19 in comparison with other forms of severe acute respiratory syndrome are lacking. This study aimed to compare the occurrence of different glycemic abnormalities in patients with severe acute respiratory syndrome and COVID-19 admitted to intensive care units versus glycemic abnormalities in patients with severe acute respiratory syndrome from other causes, to evaluate the adjusted attributable risk associated with COVID-19 and dysglycemia and to assess the influence of these dysglycemias on mortality.
Methods: We conducted a retrospective cohort of consecutive patients with severe acute respiratory syndrome and suspected COVID-19 hospitalized in intensive care units between March 11 and September 13, 2020, across eight hospitals in Curitiba-Brazil.
Background: In current management of type 2 diabetes (T2DM), cardiovascular and renal prevention have become important targets to be achieved. In this context, a joint panel of four endocrinology societies from Brazil and Portugal was established to develop an evidence-based guideline for treatment of hyperglycemia in T2DM.
Methods: MEDLINE (via PubMed) was searched for randomized clinical trials, meta-analyses, and observational studies related to diabetes treatment.
Article Synopsis
- - The study explored how two specific SNPs in the interleukin-18 gene (rs187238 and rs1946518) and one SNP in another gene (rs3212227) relate to the age at which type 1 diabetes (DM1) begins.
- - A total of 1,101 DM1 patients from various regions in Brazil participated, and their genetic profiles were analyzed using a TaqMan assay based on their ancestry.
- - Findings suggest that the SNP in the second gene might influence the age of DM1 onset due to its effect on gene expression.
Unlabelled: Objective The aims of the study were to evaluate, after pregnancy, the glycemic status of women with history of gestational diabetes mellitus (GDM) and to identify clinical variables associated with the development of type 2 diabetes mellitus (T2DM), impaired fasting glucose (IFG), and impaired glucose tolerance (IGT). Methods Retrospective cohort of 279 women with GDM who were reevaluated with an oral glucose tolerance test (OGTT) after pregnancy. Characteristics of the index pregnancy were analyzed as risk factors for the future development of prediabetes (IFG or IGT), and T2DM.
View Article and Find Full Text PDFAims: To examine the prevalence of chronic kidney disease (CKD) and its associated factors in a multinational population with type 2 diabetes mellitus (T2DM) and prior cardiovascular disease (CVD).
Methods: The LEADER trial randomized 9340 participants-81.3% with prior CVD at baseline.
Health-related quality of life in patients with type 1 diabetes mellitus in the different geographical regions of Brazil: data from the Brazilian Type 1 Diabetes Study Group.
Diabetol Metab Syndr
October 2015
Background: In type 1 diabetes mellitus (T1DM) management, enhancing health-related quality of life (HRQoL) is as important as good metabolic control and prevention of secondary complications. This study aims to evaluate possible regional differences in HRQoL, demographic features and clinical characteristics of patients with T1DM in Brazil, a country of continental proportions, as well as investigate which variables could influence the HRQoL of these individuals and contribute to these regional disparities.
Methods: This was a retrospective, cross-sectional, multicenter study performed by the Brazilian Type 1 Diabetes Study Group (BrazDiab1SG), by analyzing EuroQol scores from 3005 participants with T1DM, in 28 public clinics, among all geographical regions of Brazil.
Objective: To investigate the association between fat mass and obesity-associated (FTO) gene polymorphisms rs8050136C>A and rs9939609T>A, and transcription factor 7-like 2 (TCF7L2) gene polymorphisms rs12255372G>T and rs7903146C>T, in a sample group of pregnant Euro-Brazilian women with or without gestational diabetes mellitus (GDM).
Methods: Subjects were classified as either healthy pregnant control (n=200) or GDM (n=200) according to the 2010 criteria of the American Diabetes Association. The polymorphisms were genotyped using fluorescent probes (TaqMan®).
Objective: To investigate the association of the rs10885122G>T polymorphism in the ADRA2A gene in a Euro-Brazilian sample of healthy (controls) and type 2 diabetic (T2D) subjects.
Subjects And Methods: We used fluorescent probes (TaqMan) to genotype 241 subjects, that is, 121 healthy and 120 T2D subjects, who were classified based on the Brazilian Diabetes Association (2013) and American Diabetes Association (2014) criteria.
Results: The genotype and allele frequencies showed no significant (P > 0.
Many conditions interfere with butyrylcholinesterase (BChE) activity, e.g., pregnancy or presence of the BCHE gene variant -116A can decrease activity whereas obesity and types I and II diabetes mellitus can increase activity.
View Article and Find Full Text PDFBackground: To determine the relationship between adherence to the diet reported by patients with type 1 diabetes under routine clinical care in Brazil, and demographic, socioeconomic status, glycemic control and cardiovascular risk factors.
Methods: This was a cross-sectional, multicenter study conducted between December 2008 and December 2010 in 28 public clinics in 20 Brazilian cities. The data was obtained from 3,180 patients, aged 22 ± 11.
Objective: The objective of this study is to investigate the influence of the day-to-day variability of the measures of heart rate variability (HRV) on the sample size calculation for the study of cardiac autonomic neuropathy.
Material And Methods: We analyzed HRV in the frequency domain [very low (VLF), low (LF), and high frequency (HF) bands] and in the time domain [the root mean squared of successive RR intervals differences (RMSSD); the mean RR intervals (RRNN); the standard deviation of RR intervals (SDNN) and the coefficient of variation (CV)] during a 5-min electrocardiogram record. We also analyzed the heart rate response to deep breathing [expiration:inspiration ratio], to the Valsalva maneuver and to standing [maximum:minimum ratio] and the blood pressure response to standing.
Background: The plasma lipid profile changes atherogenically during normal pregnancy. Gestational diabetes mellitus (GDM) can exacerbate the changes in metabolism. The logarithm of the ratio triglycerides/HDL-cholesterol is an atherogenic index of the plasma (AIP) and can be used as a marker for plasma atherogenicity.
View Article and Find Full Text PDFArticle Synopsis
- * Conducted from 2008 to 2010 across 28 clinics in Brazil, the study involved 1,774 adult participants, revealing that many did not meet the recommended targets for blood pressure, LDL cholesterol, and blood sugar levels.
- * Results showed that most patients failed to achieve metabolic control and a significant number did not receive screenings for complications like retinopathy and nephropathy, increasing the risk for chronic health issues.
Objectives: To evaluate the epidemiological profile and outcomes of women with gestational diabetes mellitus (GDM), determining risk factors for increased vigilance.
Subjects And Methods: We studied 924 pregnancies in 916 patients between November 6, 2001 and September 21, 2009.
Results: Risk factors were found in 95.
Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes.
Arq Bras Endocrinol Metabol
February 2010
Objective: To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus.
Subjects And Methods: BChE activities (BChEA, AC(4/5), AC(OF) and RC(5)) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C(4/5) and C(5) complex were separated from other molecular forms (C(OF)) using an acid agar gel.