Publications by authors named "Rosane Oliveira Sant'Ana"
Article Synopsis
- The study examined the link between dietary patterns and gastric adenocarcinoma (GA) in Brazil, focusing on how certain nutrients affect this relationship.
- Researchers identified two main dietary patterns: "unhealthy dietary pattern" (UDP), which increased GA risk, and "healthy dietary pattern" (HDP), which decreased it.
- The findings revealed that added sugars and sodium intake played significant roles in mediating the effects of these dietary patterns on GA risk, providing insights for future preventive public health strategies.
Efficacy and safety results by menopausal status in monarchE: adjuvant abemaciclib combined with endocrine therapy in patients with HR+, HER2-, node-positive, high-risk early breast cancer.
Ther Adv Med Oncol
February 2023
Background: Abemaciclib is the first and only cyclin-dependent kinases 4 and 6 inhibitor approved for adjuvant treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), node-positive, and high-risk early breast cancer (EBC), with indications varying by geography. Premenopausal patients with HR+, HER2- tumors may have different tumor biology and treatment response compared to postmenopausal patients.
Objectives: We describe the efficacy and safety of abemaciclib plus endocrine therapy (ET) for the large subgroup of premenopausal patients with HR+, HER2- EBC in monarchE.
TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.
Br J Pharmacol
October 2021
Background And Purpose: Severe diarrhoea, a common gastrointestinal manifestation of anticancer treatment with irinotecan, might involve single nucleotide polymorphisms (SNPs) of toll-like receptors (TLRs), described as critical bacterial sensors in the gut. Here, colorectal cancer patients carrying missense TLR4 A896G (rs4986790) or C1,196T (rs4986791) SNPs and Tlr4 knockout (Tlr4-/-) mice were given irinotecan to investigate the severity of the induced diarrhoea.
Experimental Approach: Forty-six patients treated with irinotecan-based regimens had diarrhoea severity analysed according to TLR4 genotypes.
How does genetic testing influence anxiety, depression, and quality of life? A hereditary breast and ovarian cancer syndrome suspects trial.
Support Care Cancer
July 2021
Background: Emotional distress associated with genetic testing for hereditary breast and ovarian cancer syndrome (HBOC) is reported to interfere with adherence to treatment and prophylactic measures and compromise quality of life.
Objectives: To determine levels of anxiety, depression, and quality of life in patients tested for pathogenic BRCA1/2 mutations and identify risk factors for the development of adverse psycho-emotional effects.
Methods: Cross-sectional observational trial involving 178 breast or ovarian cancer patients from a referral cancer hospital in Northeastern Brazil.
Are pathogenic BRCA1 mutations associated with parotid mucoepidermoid carcinoma? A case report.
Oral Surg Oral Med Oral Pathol Oral Radiol
August 2021
Article Synopsis
- The case report details a 57-year-old woman with a history of multiple cancers including triple-negative breast cancer, thyroid carcinoma, and mucoepidermoid parotid carcinoma, linked to a BRCA1 mutation.
- She was diagnosed with her first breast cancer at 33, followed by subsequent tumors in the other breast and thyroid over the years.
- The findings suggest that BRCA1 mutations may also be associated with cancers outside the typical breast and ovarian types, such as salivary gland cancer.
Article Synopsis
- Gastric cancer remains a major health concern, ranking among the top five cancers worldwide, and third in cancer-related deaths, with variations in incidence and mortality rates across different regions in Brazil from 1990 to 2012.
- The study analyzed over 33,000 gastric cancer cases and approximately 23,000 deaths using data from cancer registries and mortality databases, revealing the highest incidence rates in Belem, while trends indicated a decreasing incidence in Sao Paulo and Fortaleza, but an increase for women in Belem and Fortaleza.
- Overall, while Brazil is witnessing a decrease in gastric cancer mortality rates, the Northeast region is showing troubling trends with increasing mortality, emphasizing the need for updated research and
Although the introduction of the perioperative chemotherapy on the management of gastric cancer has improved patients survival, heterogeneity of clinical outcomes has been evidenced in parallel to different histopathological regression pattern of gastric cancer cells. Thus, this study evaluated the tumor regression grading (TRG) in a series of post-treatment gastric tumors and its associations with HER2, MET, and FOXP3 expression. Material of 54 gastric cancer samples was available for TRG evaluation and immunohistochemistry.
View Article and Find Full Text PDFAs the perioperative chemotherapy has been widely implemented on the management of gastric cancer patients, heterogeneity of clinical outcomes has been evidenced in parallel to different histopathological regression pattern of gastric cancer cells. Tumor histological response to preoperative therapy has been graded by various systems in order to categorize the amount of regressive changes induced by chemotherapy in relation to residual tumor. In this context, tumor regression grading (TRG) systems might provide important prognostic information as the variety of tumor response may imply on different clinical outcomes with impact in survival rates.
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