Metabolite of tryptophan promoting changes in EEG signal and the oxidative status of the brain.

Tryptophan is an essential amino acid precursor of neurotransmitter serotonin and triptamine. During its metabolism, indole-3-acetic acid (IAA) is generated; this substance presents both antioxidant and prooxidant effects in different biological systems in addition to hipoglicemic effects. To date, electroencephalography (EEG) has been used to evaluate the temporal effect of several substances in neurotransmission.

Guanidine affects differentially the twitch response of diaphragm, extensor digitorum longus and soleus nerve-muscle preparations of mice.

Guanidine has been used with some success to treat myasthenia gravis and myasthenic syndrome because it increases acetylcholine release at nerve terminals through K⁺, Na⁺ and Ca²⁺ channels-involving mechanisms. Currently, guanidine derivatives have been proposed for treatment of several diseases. Studies aimed at providing new insights to the drug are relevant.

Stability constants: a new twist in transition metal bispidine chemistry.

Transition metal complexes with 2,4-substituted tetradentate, 2,3,4- and 2,4,7-substituted pentadentate, and 2,3,4,7-substituted hexadentate bispidine ligands (bispidine = 3,7-diazabicyclo[3.3.1]nonane) with two tertiary amine and two, three, or four pyridine donors are relatively stable (10 < log K(CuL) < 18).

Coordination chemistry of a new rigid, hexadentate bispidine-based bis(amine)tetrakis(pyridine) ligand.

The hexadentate bispidine-based ligand 2,4-bis(2-pyridyl)-3,7-bis(2-methylenepyridine)-3,7-diazabicyclo[3.3.1]nonane-9-on-1,5-bis(carbonic acid methyl ester), L(6m), with four pyridine and two tertiary amine donors, based on a very rigid diazaadamantane-derived backbone, is coordinated to a range of metal ions.