Publications by authors named "Rosalind Wright"

Executive functioning (EF) has been linked to chronic disease risk in children. Health behaviors are thought to partially explain this association. The current cross-sectional study evaluated specific domains of EF and varied health behaviors in three pediatric life stages.

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Purpose: The Environmental influences on Child Health Outcomes (ECHO) Cohort has enrolled over 60,000 children to examine how early environmental factors (broadly defined) are associated with key child health outcomes. The ECHO Cohort may be well-positioned to contribute to our understanding of rural environments and contexts, which has implications for rural health disparities research. The present study examined the outcome of child obesity to not only illustrate the suitability of ECHO Cohort data for these purposes but also determine how various definitions of rural and urban populations impact the presentation of findings and their interpretation.

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Early life environmental exposures, even those experienced before conception, can shape health and disease trajectories across the lifespan. Optimizing the detection of the constellation of exposure effects on a broad range of child health outcomes across development requires considerable sample size, transdisciplinary expertise, and developmentally sensitive and dimensional measurement. To address this, the National Institutes of Health (NIH) Environmental influences on Child Health Outcomes (ECHO) Cohort Study is an observational longitudinal pediatric cohort study.

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  • Prenatal exposure to ozone (O) might influence child lung function, particularly through oxidative stress, and diet may play a role in modifying these effects.
  • In a study of 661 women in the CANDLE cohort, no significant associations were found between prenatal O exposure and lung function; however, there were hints of adverse effects during specific fetal development periods.
  • Interactions between maternal diet (OBS) and race did not consistently modify the effects of O, although some associations were noted among specific racial groups under certain dietary conditions.
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  • The study investigates the link between maternal lifetime stress and child asthma, exploring how factors like maternal pre-pregnancy body mass index and race/ethnicity might affect this relationship.
  • Higher maternal stress was found to significantly increase the likelihood of child asthma, particularly among mothers categorized as obese.
  • The results suggest that understanding the interplay of various factors is crucial in addressing how maternal stress impacts children's health, especially regarding asthma in early childhood.
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Objectives: Posttraumatic stress disorder (PTSD) is a disabling mental health condition arising from experiencing serious traumatic events. This study investigated if PTSD secondary to the World Trade Center terrorist attack on 11 September 2001 (9/11) is associated with self-reported doctor's diagnosis of periodontitis and count of missing teeth.

Methods: Data from the World Trade Center Health Registry, 2003-2020 (n = 20 826) were used to prospectively examine the rate of periodontitis and cross-sectionally the odds of missing teeth among enrolees with/without PTSD post-9/11 using a modified Poisson regression and generalised logit model, respectively, adjusted for covariates.

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Background: Prenatal air pollution (AP) exposure has been linked to postpartum psychological functioning, impacting health outcomes in both women and children. Extant studies primarily focused on individual pollutants.

Objective: To assess the association between prenatal exposure to a mixture of seven AP components and postpartum psychological functioning using daily exposure data and data-driven statistical methods.

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  • - Prenatal and early-life exposure to air pollution and extreme temperatures are linked to increased risks of asthma and wheezing in children, but the specific vulnerable periods and how these effects vary by sex remain unclear.
  • - The study analyzed data from 468 mother-child pairs in Mexico City, finding that exposure to particulate matter (PM) and nitrogen oxides (NO) during mid-gestation and the first year of life significantly increased the odds of wheeze, with some temperature effects being less consistent.
  • - Results indicated that the impact of air pollution on respiratory issues is stronger in males, and a combined high exposure to PM and temperature during infancy led to an increased risk of wheeze.
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  • The study aimed to explore the link between prenatal iodine intake (dietary and supplemental) and infant temperament, noting the importance of iodine for fetal neurodevelopment.
  • Conducted within the PRISM study from 2011 to 2020, data from 892 mother-child pairs indicated that many women had inadequate iodine intake, with 49% falling below recommended levels.
  • Results showed that girls whose mothers had adequate iodine intake displayed higher levels of extraversion, while boys showed statistically insignificant higher negative affectivity, suggesting low iodine intake could affect infant temperament and early neurodevelopment.
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  • Background research highlights that prenatal exposure to ambient fine particulate matter (PM) may negatively affect child lung health, yet studies specifically investigating the timing of exposure during critical lung development phases are limited.
  • The study involved 675 children, tracking prenatal PM exposure and assessing lung function at ages 8-9 through spirometry while controlling for various factors like maternal and child characteristics.
  • Results showed weak associations between PM exposure during specific fetal development phases and lung function measures (FEV1 and FVC), with no significant effect from factors like child sex or allergic sensitization.
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  • Data integration from multiple studies boosts statistical power to investigate links between environmental exposure mixtures and health outcomes, while addressing variations across different studies.
  • The hierarchical Bayesian Weighted Quantile Sum (HBWQS) method aggregates data from various cohorts to identify harmful exposures and their specific impacts on health outcomes, outperforming the traditional BWQS method.
  • The findings indicate that HBWQS can guide regulations and interventions related to environmental exposures by effectively combining cohort data and adjusting for differences between them.
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Background: Residential food environment influences dietary patterns, however the impact of individuals' perceived social identity on their antioxidant intake, an indicator of healthy dietary patterns, remains underexplored.

Objective: We conducted a cross-sectional analysis using data collected in a longitudinal cohort. In the study, we aimed to investigate the interactions between the food environment and two indicators of social identity, specifically a subjective ladder measure of socioeconomic status (SES) and the Multigroup Ethnic Identity Measure (MEIM) score, in relation to dietary antioxidant intake (DAI) among n = 512 Boston and NYC-resident pregnant women.

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  • Prenatal exposure to phthalates, specifically during the 2nd trimester, is linked to an increased risk of wheezing and asthma in children, with data obtained from a study of 593 mother-child pairs in Mexico City.
  • Higher levels of certain phthalate metabolites were associated with wheezing and asthma, particularly among male children, indicating potential sex differences in vulnerability.
  • The study utilized advanced statistical methods to analyze phthalate mixtures, revealing that prenatal exposure effects on respiratory issues varied by trimester and child gender, suggesting the need for more focused research in Latin American populations.
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Importance: Limited access to healthy foods, resulting from residence in neighborhoods with low food access, is a public health concern. The contribution of this exposure in early life to child obesity remains uncertain.

Objective: To examine associations of neighborhood food access during pregnancy or early childhood with child body mass index (BMI) and obesity risk.

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Background: Telomere length is a biomarker of molecular aging that may be impacted by air pollution exposure starting in utero. We aimed to examine the association between prenatal and early life exposure to fine particulate matter (PM) and leukocyte telomere length (LTL) in children and explore sex differences.

Methods: Analyses included 384 mother-child pairs enrolled in the Programming Research in Obesity, Growth, and Environmental Stressors (PROGRESS) birth cohort in Mexico City.

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Background: Evidence suggests historical redlining shaped the built environment and health outcomes in urban areas. Only a handful of studies have examined redlining's association with air pollution and adverse birth outcomes in New York City (NYC). Additionally, no NYC-specific studies have examined the impact of redlining on birth weight.

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  • There is a lack of thorough longitudinal studies on how the COVID-19 pandemic has impacted children's mental health over time, particularly regarding variations among different subgroups.
  • The study aims to assess changes in youth mental health from before the pandemic to the middle of it, using data from the Environmental influences on Child Health Outcomes (ECHO) Program.
  • Results showed that of 1,229 participants, there were minor decreases in levels of externalizing behaviors, indicating subtle shifts in mental health throughout the pandemic while accounting for various sociodemographic factors.
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Background: Reducing the risk of respiratory disease during the plastic stages of lung development could have long-term health impacts. Psychosocial stress has been previously linked to adverse childhood respiratory outcomes, but the influence of child's anxiety and sex differences has not been completely elucidated.

Objective: To evaluate the association among maternal stress, child anxiety, and lung function in children and to explore differences by sex.

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Globally, catadromous freshwater eels of the genus Anguilla are of conservation concern, including critically endangered European eel (Anguilla anguilla). Pumping stations that move river water to a higher elevation severely impact eels during their seaward spawning migration. Fish-friendly pumps can mitigate fish injury and mortality but here we uniquely rethink a fish-friendly pump as a fish passage solution.

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Background: We investigated the individual and interaction effects of maternal plasma 𝛂- and ϒ-tocopherol levels (vitamin E isomers) on child asthma and wheeze at age 8-9.

Methods: Mother-child dyads were enrolled between 2006 and 2011 into the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) prenatal cohort. Maternal second-trimester samples were analyzed for tocopherol and lipid concentrations.

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Background: Prenatal fish intake is a key source of omega-3 (ω-3) polyunsaturated fatty acids needed for brain development, yet intake is generally low, and studies addressing associations with autism spectrum disorder (ASD) and related traits are lacking.

Objective: This study aimed to examine associations of prenatal fish intake and ω-3 supplement use with both autism diagnosis and broader autism-related traits.

Methods: Participants were drawn from 32 cohorts in the Environmental influences on Child Health Outcomes Cohort Consortium.

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: Emerging evidence suggests that essential trace elements, including iodine, play a vital role in depressive disorders. This study investigated whether prenatal dietary iodine intake alone and in combination with supplemental iodine intake during pregnancy were associated with antepartum and postpartum depressive and anhedonia symptoms. : The study population included 837 mothers in the PRogramming of Intergenerational Stress Mechanisms (PRISM) study.

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Early life phthalates exposure has been associated with adverse respiratory outcomes. However, evidence linking prenatal phthalates exposure and childhood lung function has been inconclusive. Additionally, few studies have examined phthalates exposure as a mixture and explored sexually dimorphic associations.

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Background: Metal(oid)s have been cross-sectionally associated with lung function outcomes in childhood but there is limited data on their combined effects starting in utero. Child sex may further modify these effects.

Objective: Examine associations between in utero and early life exposure to metals assessed via novel dentine biomarkers and childhood lung function and explore effect modification by child sex.

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