Colorectal cancer in patients under close colonoscopic surveillance.

Background & Aims: Colonoscopic polypectomy is considered effective for preventing colorectal cancer (CRC), but the incidence of cancer in patients under colonoscopic surveillance has rarely been investigated. We determined the incidence of CRC in patients under colonoscopic surveillance and examined the circumstances and risk factors for CRC and adenoma with high-grade dysplasia.

Methods: Patients were drawn from 3 adenoma chemoprevention trials.

A randomized trial of aspirin to prevent colorectal adenomas.

Background: Laboratory and epidemiologic data suggest that aspirin has an antineoplastic effect in the large bowel.

Methods: We performed a randomized, double-blind trial of aspirin as a chemopreventive agent against colorectal adenomas. We randomly assigned 1121 patients with a recent history of histologically documented adenomas to receive placebo (372 patients), 81 mg of aspirin (377 patients), or 325 mg of aspirin (372 patients) daily.

Familial and inherited colorectal cancer: endoscopic screening and surveillance.

Familial risk of colorectal cancer is very common. The high-risk inherited syndromes are well described and much is known about the genetics and the effectiveness of registration, endoscopic surveillance, and appropriate intervention in these patients. The inherited syndromes, however, are extremely rare.