Combination of Proton Therapy and Radionuclide Therapy in Mice: Preclinical Pilot Study at the Paul Scherrer Institute.

Proton therapy (PT) is a treatment with high dose conformality that delivers a highly-focused radiation dose to solid tumors. Targeted radionuclide therapy (TRT), on the other hand, is a systemic radiation therapy, which makes use of intravenously-applied radioconjugates. In this project, it was aimed to perform an initial dose-searching study for the combination of these treatment modalities in a preclinical setting.

Comparative study of FAST gradient echo MRI sequences: phantom study.

Purpose: To investigate a balanced steady state free precession sequence (b-SSFP) under a large range of conditions and to compare its performance with other types of gradient echo sequences for dynamic imaging.

Materials And Methods: Balanced turbo field echo (b-TFE; Philips Medical Systems, Best, The Netherlands) was investigated in vitro at a range of T2/T1 along with T1-contrast enhanced turbo field echo (T1-TFE) and turbo field echo (TFE) so that a comparison could be made. Performance was quantified in terms of the initial slope of the signal-to-noise ratio (SNR) vs.