P013 Resolution of Infliximab Associated Infusion Hypersensitivity After Switching to Biosimilar Infliximab-dyyb.

Case: Background: Administration of infliximab for the treatment of inflammatory bowel disease has a well-recognized risk of infusion-related (IR) adverse events. The recent introduction of the biosimilar infliximab-dyyb (Inflectra®) has been shown to have similar efficacy with comparable safety profile when compared to infliximab; however, although the active ingredients are similar, the inactive ingredients are different. We present a case of a 26-year-old female with ulcerative colitis who had resolution of her IR hypersensitivity when switched from infliximab to infliximab-dyyb.

Hypothyroidism after craniospinal irradiation with proton or photon therapy in patients with medulloblastoma.

Background: Craniospinal irradiation (CSI) often results in endocrine deficiencies in children with medulloblastoma due to irradiation of the hypothalamic-pituitary axis (HPA) or the thyroid gland. CSI with Proton radiation therapy (PRT) has the potential to decrease the risk of hypothyroidism by reduction in radiation dose to these organs. This study compares the risk for hypothyroidism in patients with medulloblastoma treated with Photon radiation therapy (XRT) or PRT.

Predictors of Suboptimal Follow-up in Pediatric Cancer Survivors.

Attendance to follow-up care after completion of cancer treatment is an understudied area. We examined demographic, clinical, and socioeconomic predictors of follow-up by pediatric cancer patients at a large center in 442 newly diagnosed patients using multivariable logistic regression analyses. Patients who did not return to clinic for at least 1000 days were considered lost to follow-up.

APHON/ASPHO Policy Statement for the Transition of Patients With Sickle Cell Disease From Pediatric to Adult Health Care.

Unlabelled: With advances in medical care, the majority of children with sickle cell disease are surviving to adulthood. Patients, families, and providers now face the need for this growing population to move from pediatric- to adult-focused care. In order to facilitate a successful transfer to adult health care, and prepare young adults for greater independence, it is recommended that all pediatric patients with sickle cell disease receive transition preparation.

Enhancing pediatric oncology nursing care through research, quality improvement, and evidence-based practice.

Research, quality improvement (QI), and evidence-based practice (EBP) are knowledge-based methods used to enhance nursing practice. Nurses need to conduct studies to fill empirical gaps of knowledge (research), continually monitor health care practices and processes (QI), and systematically compile and review evidence (EBP). Research, QI, and EBP are valuable instruments within the health care setting as they can benefit the patient, families, health care team members, and the nursing profession, but it is important to understand when and how to use each method.

Human papillomavirus vaccination in female pediatric cancer survivors.

Study Objective: Survivors of childhood malignancy may be at increased risk for HPV infection for biological and cognitive/behavioral reasons. HPV vaccination is currently recommended for females 11-12 years old with catch up vaccination up to age 26 years. The objective of this cross-sectional study was to determine the prevalence of HPV vaccination among female pediatric cancer survivors, age 11-18 years, at Texas Children's Hospital.

Nausea and vomiting perspectives among children receiving moderate to highly emetogenic chemotherapy treatment.

Background: Chemotherapy-induced nausea and vomiting (CINV) are common adverse effects, but occurrences among pediatric oncology patients are not well documented.

Objective: The primary aim was to describe anticipatory, acute, and delayed CINV among children with cancer from the child's, caregiver's, and nurse's perspective. A secondary aim evaluates the correlation of CINV among the child's, caregiver's, and nurse's perspectives.

Transition of chronically ill youth to adult health care: experience of youth with hemoglobinopathy.

Introduction: The purpose of this study was to describe the transition experience, expectations, and concerns of chronically ill youth with hemoglobinopathy (CIYH) (e.g., sickle cell disease) who have transitioned to adult health care.

Transition of the chronically ill youth with hemoglobinopathy to adult health care: an integrative review of the literature.

With the advent of innovative technologies and medical advances, more than a half million chronically ill youth (CIY) cross the threshold into adulthood yearly. Successful transition of the CIY with hemoglobinopathy (e.g.

Asthma in the pediatric sickle cell patient with acute chest syndrome.

Introduction: Acute chest syndrome (ACS) is a potential life-threatening complication of sickle cell disease (SCD). The purpose of this study was to identify the frequency of asthma in children with SCD who were diagnosed with ACS. The objective was to determine if an increased frequency of asthma exists in children with SCD and ACS.

Managing side effects of childhood cancer treatment.

This article focuses on the nurse's role as a member of the supportive care team for the child diagnosed with cancer and the family. The most common side effects of the cancer treatment are discussed in depth in this article. The adequate management of the side effects experienced by the child receiving cancer therapy may greatly influence the child's quality of life.

Three instruments to assess fatigue in children with cancer: the child, parent and staff perspectives.

The purpose of this study was to develop and test three instruments to measure fatigue in children with cancer from the perspectives of the child, parents and staff. The study consisted of three phases: instrument development, content validation, and estimations of psychometric properties of the three fatigue instruments. One hundred forty-nine children between the ages of 7-12 years presently receiving chemotherapy for cancer, 147 parents and 124 staff participated in this study.