Publications by authors named "Rosalin M Dubois"
Article Synopsis
- The study focuses on the antibody response to the Moderna Spikevax COVID-19 vaccine, highlighting the importance of understanding this immune response to pathogens.
- It introduces a new method that combines mass spectrometry and B-cell sequencing to analyze human plasma-derived polyclonal IgG, addressing limitations in traditional B-cell repertoire sequencing.
- The researchers created 12 recombinant antibodies from their sequencing data, with six showing strong binding affinities and neutralizing capabilities against the target antigen.
Background: Standard methods assessing pain in rodents are often observer dependent, potentially resulting in biased outcomes. Advanced dynamic weight bearing (ADWB) offers an observer-independent approach that can provide objective, reliable data in preclinical pain research.
Aims: The aim of this study was to characterize the use of ADWB in assessing murine responses to allyl isothiocyanate (AITC)-induced hyperacute hypersensitivity and identify best practices for use of the device.
Motor disability in multiple sclerosis is often modeled using experimental autoimmune encephalomyelitis (EAE) and assessed using the clinical score (CS), an observer-dependent tool that can lead to potential bias. The Advanced Dynamic Weight Bearing (ADWB) system was evaluated as an observer-independent measurement of EAE symptoms. ADWB detected weight shifts onto the front paws as mice develop hindlimb motor disability.
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