Publications by authors named "Rosalie Douglas"
Article Synopsis
- This study investigates the impact of pathological lymph node (LN) regression after neoadjuvant chemotherapy on survival rates in patients with esophageal adenocarcinoma, addressing a gap in existing research and defining LN response classifications.
- Conducted across five UK centers, the study analyzed 17,930 LNs from 763 patients, assigning scores based on the extent of residual tumor found in the nodes after treatment, with survival outcomes assessed using advanced statistical methods.
- Results showed that patients with complete or partial LN response had significantly lower mortality rates compared to those with poor or no LN response, highlighting LN regression as a vital prognostic factor that should be considered alongside traditional staging methods.
Drug resistance limits the effectiveness of oesophageal adenocarcinoma (OAC) chemotherapies, leading to a poor prognosis for this disease. Elucidation of the underlying resistance mechanisms is key to enabling the identification of more effective treatments. This study, therefore, aims to identify novel therapeutic and/or chemotherapy sensitising drug targets in OAC.
View Article and Find Full Text PDFObjective: Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC.
Design: Transcriptional profiling of 273 formalin-fixed paraffin-embedded prechemotherapy endoscopic OAC biopsies was performed.