Publications by authors named "Rosalia Curto"

Insulin is the primary autoantigen (Ag) targeted by T cells in type 1 diabetes (T1D). Although biomarkers precisely identifying subjects at high risk of T1D are available, successful prophylaxis is still an unmet need. Leaky central tolerance to insulin may be partially ascribed to the instability of the MHC-InsB complex, which lowers TCR avidity, thus resulting in defective negative selection of autoreactive clones and inadequate insulin-specific T regulatory cell (Treg) induction.

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Liver gene therapy with adeno-associated viral (AAV) vectors delivering clotting factor transgenes into hepatocytes has shown multiyear therapeutic benefit in adults with hemophilia. However, the mostly episomal nature of AAV vectors challenges their application to young pediatric patients. We developed lentiviral vectors, which integrate in the host cell genome, that achieve efficient liver gene transfer in mice, dogs and non-human primates, by intravenous delivery.

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Type 1 diabetes (T1D) is a chronic autoimmune disease resulting in progressive destruction of β-cells. Several factors affecting lymphocyte and antigen-presenting cells, including dendritic cells (DCs), contribute to defective maintenance of tolerance in T1D. DC-10 are a subset of human DCs involved in IL-10-mediated tolerance.

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Article Synopsis
  • IPEX syndrome is a severe autoimmune disease caused by mutations in the FOXP3 gene, which is essential for the proper function of regulatory T cells (Treg), leading to a lack of immune regulation.
  • The primary treatment for IPEX patients is hematopoietic stem cell transplantation, but if unavailable, other immunosuppressive therapies have been less effective, though rapamycin shows promise in preserving Treg function while suppressing harmful immune responses.
  • Research on six IPEX patients revealed that rapamycin treatment led to improved Treg cell function and clinical outcomes, highlighting increased expression of specific proteins associated with Treg activity, which could help develop better therapies for the disease.
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