A Preliminary Investigation of Abnormal Personality Traits in MS Using the MCMI-III.

Neuropsychiatric abnormalities are frequently reported in patients with multiple sclerosis (MS). Previous studies have investigated the neurotic aspects of psychopathology, and the importance of the personality structure underlying neurotic symptoms has only recently been reconsidered. The aim of our study was to investigate the frequency and type of personality profiles in MS using the Millon Clinical Multiaxial Inventory-III (MCMI-III).

Exploration of the relationships between regional grey matter atrophy and cognition in multiple sclerosis.

Cognitive impairment may result in significant disability in patients with Multiple Sclerosis (MS). Previous Magnetic Resonance Imaging (MRI) studies on cognition in MS were mainly based on measures of gross brain involvement. This study, using voxel-based morphometry (VBM), aims to investigate associations between the regional distribution of grey matter (GM) damage and cognitive performance in patients with MS.

Multiparametric MR investigation of the motor pyramidal system in patients with 'truly benign' multiple sclerosis.

One possible explanation for the mismatch between tissue damage and preservation of neurological functions in patients with benign multiple sclerosis (BMS) is that the pathophysiology differs from that occurring in other multiple sclerosis (MS) phenotypes. The objective of this study was to identify pathologically specific patterns of tissue integrity/damage characteristics of patients with BMS, and markers of potential prognostic value. The pyramidal system was investigated in 10 BMS patients and 20 controls using voxel-based morphometry to assess grey matter (GM) atrophy, and diffusion tractography and quantitative magnetization transfer to quantify the microstructural damage in the corticospinal tracts (CSTs).