Publications by authors named "Rosa Papadantonaki"
Article Synopsis
- The study aimed to create a standardized core outcome set (COS) for heavy menstrual bleeding (HMB) by following the COMET initiative methodology.
- The process involved four phases: a systematic review to identify potential outcomes, qualitative studies with patients to understand their priorities, a Delphi survey for consensus, and a final meeting to finalize the COS.
- The resulting COS includes 10 key outcomes relevant for clinical trials and guidelines, ensuring comprehensive reporting in future studies of HMB interventions.
The cell's response to hypoxia depends on stabilization of the hypoxia-inducible factor 1 complex and transactivation of nuclear factor kappa-B (NF-κB). HIF target gene transcription in cells resident to atherosclerotic lesions adjoins a complex interplay of cytokines and mediators of inflammation affecting cholesterol uptake, migration, and inflammation. Maladaptive activation of the HIF-pathway and transactivation of nuclear factor kappa-B causes monocytes to invade early atherosclerotic lesions, maintaining inflammation and aggravating a low-oxygen environment.
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