Publications by authors named "Rosa Maria Giraldez-Perez"
Pigment epithelium-derived factor (PEDF) is a multifunctional protein which was initially described in the retina, although it is also present in other tissues. It functions as an antioxidant agent promoting neuronal survival. Recently, a PEDF receptor has shown an elevated binding affinity for PEDF.
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- Obesity-related metabolic diseases are linked to issues with how adipose tissue (AT) handles lipids and inflammation, potentially influenced by gut-derived lipopolysaccharides (LPSs).
- A study involving 33 obesity patients revealed that those with higher LPS levels showed decreased expression of essential AT function and lipogenesis genes and increased inflammatory gene expression.
- In vitro experiments confirmed that LPS contributes to AT inflammation and disrupts key gene expressions related to lipid handling, suggesting metabolic endotoxemia negatively affects AT physiology in human obesity.
A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs16969681, is also associated with CRC susceptibility, conferring ∼20% differential risk in the general population.
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