L-propionyl-carnitine protects tissues from ischaemic injury in an 'in vivo' human ischaemia-reperfusion model.

Objective: To assess the acute effects of L-propionyl-carnitine (LPC) on vaso-motion, tissue perfusion and tissue acidosis during an ischaemia-reperfusion test in patients with intermittent claudication.

Design: Open pharmacodynamic study.

Study Participants: Sixteen male patients with intermittent claudication (mean absolute claudication distance 193.