Publications by authors named "Rosa M Tommasoli"
Article Synopsis
- The study investigates the connection between platelet activation and inflammation in patients with varying stages of peripheral arterial occlusive disease (PAOD), compared to matched controls.
- Findings reveal increased levels of platelet activation markers in PAOD patients, with a correlation between platelet activation (measured by urinary 11-dehydrothromboxane B(2)) and the inflammatory marker C-reactive protein (CRP).
- While chronic low-dose acetylsalicylic acid treatment reduced 11-dehydrothromboxane levels, it did not significantly affect platelet-monocyte aggregates or CRP levels, indicating that platelet activation is closely tied to inflammation severity in PAOD patients.
Signals ensuing from trimeric G-protein-coupled receptors synergize to induce platelet activation. At low doses, the thromboxane A2 analogue U46619 does not activate integrin alphaIIbbeta3 or trigger platelet aggregation, but it induces shape changes. In the present study, we addressed whether low doses of U46619 trigger tyrosine phosphorylation independently of integrin alphaIIbbeta3 activation and ADP secretion, and synergize with adrenaline (epinephrine) to induce aggregation in acetylsalicylic acid (aspirin)-treated platelets.
View Article and Find Full Text PDFWe investigated similarities in the signaling pathways elicited by the F2 isoprostane 8-iso-PGF2alpha and by low doses of U46619 to induce platelet activation. Both 0.01-0.
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