Publications by authors named "Rosa M Martin-Rodriguez"
Treatment with 1.25% cholesterol enriched diet produces severe fatty liver disease characterized by advanced fibrosis and inflammation and impaired autophagy in mice.
Alida Taberner-Cortés María Aguilar-Ballester Elena Jiménez-Martí Gema Hurtado-Genovés Rosa M Martín-Rodríguez
J Nutr Biochem
December 2024
Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common due to poor dietary habits, making it essential to study its advanced stages for better understanding.
- A study feeding WT mice a high-fat, sugar, and cholesterol diet (HFSCD) for 16 weeks revealed significant liver damage, increased triglycerides, and advanced disease indicators compared to a control diet.
- The HFSCD diet also led to changes in immune cell populations and gene expression related to metabolism and inflammation, indicating a complex interaction between diet and liver pathology, contributing to the severity of NAFLD.