Publications by authors named "Rosa M Garcia-Centeno"
Early detection of high oxidative activity in patients with adenomatous intestinal polyps and colorectal adenocarcinoma: myeloperoxidase and oxidized low-density lipoprotein in serum as new markers of oxidative stress in colorectal cancer.
Jesús Crespo-Sanjuán María D Calvo-Nieves Beatriz Aguirre-Gervás José Herreros-Rodríguez Benito Velayos-Jiménez
Lab Med
July 2016
Objectives: To detect whether signs of oxidative stress appear at early stages of colorectal adenocarcinoma (CRC), particularly in the polyp stage. We also aimed to evaluate the specific entities myeloperoxidase (MPO) and oxidized low-density lipoprotein (oxLDL) as novel markers of oxidation in the plasma of patients with CRC and to study the relationship between oxidative status in plasma and patient survival.
Methods: We assayed serum or plasma specimens from healthy control subjects (n = 14), from patients with intestinal polyps (n = 39), and from patients with CRC (n = 128) to calculate the modified oxidative balance score (MOBS) using several serum markers (β-carotene, lycopene, vitamin A, vitamin E, MPO, and oxLDL).
Article Synopsis
- ApoD expression is inversely correlated with tumor growth in colorectal cancer (CRC), suggesting its potential as a prognostic marker and therapeutic tool.
- The study examined the relationship between lipid peroxidation, oxidative stress-related gene expression, and ApoD levels in CRC tissues, finding that ApoD protein decreases as the tumor progresses.
- While ApoD does not affect cell proliferation or apoptosis in normal conditions, it promotes apoptosis in CRC cells under oxidative stress, highlighting its role in the tumor microenvironment.