Metallocene catalyzed synthesis of fungistatic vicinal aminoalcohols under solvent free conditions.

Group 4 and 5 metallocenes, Cp(2)TiCl(2), Cp(2)ZrCl(2) and Cp(2)VCl(2), have been evaluated as catalyst in the solvent free, room temperature, preparation of vicinal aminoalcohols. The regioselectivity of the reaction and the fungistatic activity of the prepared compounds against Botrytis cinerea and Colletotrichum gloeosporioides are discussed.

Biosynthetic studies on the botcinolide skeleton: new hydroxylated lactones from Botrytis cinerea.

[reaction: see text] The biosynthetic origin of the botcinolide skeleton was investigated by means of feeding 13C- and 2H-labeled precursors to Botrytis cinerea. Three new compounds, two homobotcinolide derivatives, 3-O-acetylhomobotcinolide (5) and 8-methylhomobotcinolide (6), and a new 11-membered lactone (7), were isolated. Their structures were elucidated on the basis of spectroscopic data, including one-bond and long-range 1H-13C correlations.

Four new lactones from Botrytis cinerea.

Four new lactones (1-4) have been isolated from Botrytis cinerea. Their structures were elucidated by interpretation of spectral data, mainly (1)H and (13)C NMR, including two-dimensional analysis (HOMOCOSY, HMQC, and HMBC). The phytotoxic activities of these new natural products have been evaluated.