Publications by authors named "Rosa M Benitez"

Background: Disseminated tuberculosis is frequently associated with delayed diagnosis and a poorer prognosis.

Objectives: To describe case series of disseminated TB and diagnosis delay in a low TB burden country during the COVID-19 period.

Methodology: We consecutively included all patients with of disseminated TB reported from 2019 to 2021 in the reference hospital of the Northern Crown of the Metropolitan Area of Barcelona.

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Background: Prophylactic vaccination has proven to be the most effective strategy to fight the COVID-19 pandemic.

Methods: This was a prospective observational cohort study involving 30 predominantly antibody deficiency disorders (ADD)-afflicted adult patients on immunoglobulin replacement therapy vaccinated with three doses of the mRNA-1273 COVID-19 vaccine, and 10 healthy controls. Anti-RBD IgG antibodies were determined in plasma samples collected just before the first dose of mRNA-based COVID-19 vaccine and on weeks 4, 8, 24, and 28 following the first vaccination.

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Article Synopsis
  • Mass vaccination campaigns have effectively lowered COVID-19 cases and severity, and this study examined the immune responses of patients with primary antibody deficiencies (PAD) after receiving three doses of the mRNA-1273 vaccine.
  • Patients were categorized into groups based on their specific immunodeficiencies, and while unclassified PAD (unPAD) patients and healthy controls showed similar antibody responses after two doses, those with common variable immunodeficiency (CVID) exhibited weaker responses.
  • The third vaccine dose improved antibody levels in most PAD patients but had little effect on enhancing cellular immunity, highlighting the need for individualized monitoring and treatment strategies for PAD individuals.
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is a human zoonotic pathogen of occupational origin, with infection acquired through contact with live pigs or pig meat. Pig farming is one of Catalonia's biggest industries and as a result this region of Spain has one of the highest density pig populations per km. The aim of our study was to describe the infections caused by occurring in that area over a 9-year period.

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Introduction: Methicillin-susceptible (MSSA) bacteraemia is a frequent condition, with high mortality rates. There is a growing interest in identifying new therapeutic regimens able to reduce therapeutic failure and mortality observed with the standard of care of beta-lactam monotherapy. In vitro and small-scale studies have found synergy between cloxacillin and fosfomycin against .

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