Publications by authors named "Rosa M Agra-Bermejo"
Post-operative atrial fibrillation (POAF) is the most common arrhythmia in the post-operative period after cardiac surgery. We aim to investigate the main clinical, local, and/or peripheral biochemical and molecular predictors for POAF in patients undergoing coronary and/or valve surgery. Between August 2020 and September 2022, consecutive patients undergoing cardiac surgery without previous history of AF were studied.
View Article and Find Full Text PDFAim: Whether Takotsubo syndrome (TTS) should be classified within myocardial infarction with non-obstructive coronary arteries (MINOCAs) is still controversial. The aim of this work was to evaluate the main differences between TTS and non-TTS MINOCAs.
Methods And Results: A cohort study based on two prospective registries: TTS from the RETAKO registry (:1,015) and patients with non-TTS MINOCAs from contemporary records of acute myocardial infarction from five 5 national centers (:1,080).
Inflammation is one of the mechanisms involved in heart failure (HF) pathophysiology. Thus, the acute phase reactant protein, orosomucoid, was associated with a worse post-discharge prognosis in acute HF (AHF). However, the presence of anti-inflammatory adipokine, omentin, might protect and reduce the severity of the disease.
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- The study analyzes cardiovascular outcomes in patients with diabetes mellitus who are experiencing non-ST elevation acute coronary syndrome (NSTEACS) and evaluates the effectiveness of two risk assessment scores: GRACE and PRECISE-DAPT.
- A total of 7,415 patients were included, with 28% having diabetes; findings revealed diabetic patients were generally older and had higher initial risk scores, with differences in treatment approaches observed.
- The PRECISE-DAPT score effectively predicted mortality and adverse cardiovascular events in diabetic patients, while the GRACE score performed worse over the long term for these individuals.
Article Synopsis
- The study examines the relationship between epicardial adipose tissue (EAT), associated factors like diabetes and obesity, and ACE2 levels, which are important for COVID-19 risk.
- Researchers analyzed fat biopsies from 43 patients during open-heart surgery, measuring gene expression for ACE1, ACE2, and ADAM17.
- Results showed that EAT had higher ACE2 levels linked to diabetes and obesity, suggesting that these conditions may increase the risk of severe COVID-19 outcomes.
Objectives: Neurohormonal dysfunction, which can regulate epicardial fat activity, is one of the main promoters of atrial fibrillation (AF) in patients with heart failure (HF). Our aim was to study the epicardial fat mediators for AF in patients with HF and its catecholaminergic regulation.
Methods: We have included 29 patients with HF who underwent cardiac surgery and were followed up for 5 years.
Article Synopsis
- Acute coronary syndromes include a specific type called MINOCA, which involves myocardial infarction without significant blockage in coronary arteries and affects younger, predominantly female patients with fewer risk factors.
- * MINOCA has different causes, including issues with epicardial arteries (like plaque disruption) and microvascular problems (like spasms or takotsubo syndrome), making it crucial to identify the underlying mechanism for proper treatment and prognosis.
- * The diagnosis of MINOCA involves various tests, including coronary angiography and cardiac imaging, and standardizing care through future clinical trials could improve outcomes for these patients.
Background And Aims: Dapagliflozin, a sodium-glucose co-transporter 2 inhibitor, improves glucose uptake by epicardial adipose tissue (EAT). However, its metabolism might raise the lactate production and acidosis under hypoxia conditions, i.e.
View Article and Find Full Text PDFBotulinum toxin injection on epicardial fat, which inhibits acetylcholine (ACh) release, reduced the presence of atrial fibrillation (AF) in patients after heart surgery. Thus, we wanted to study the profile of the released proteins of epicardial adipose tissue (EAT) under cholinergic activity (ACh treatment) and their value as AF predictors. Biopsies, explants, or primary cultures were obtained from the EAT of 85 patients that underwent open heart surgery.
View Article and Find Full Text PDFA obesity paradox has been described following heart failure (HF). The aim of this study was to analyze the association between food intake-involved adipokines and long-term weight changes. Leptin, adiponectin, and omentin were analyzed in 92 acute HF (AHF) patients at discharge, classified on the basis of weight gains or losses > 6%.
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- The study investigates the long-term outcomes of cardiac resynchronization therapy (CRT) in heart failure patients, focusing on whether they received optimal medical therapy (OMT) before or after the CRT device implantation.
- Out of 328 patients, those who received OMT at the 1-year follow-up showed a lower risk of heart failure and death compared to patients who did not receive OMT.
- The findings suggest that initial OMT prior to CRT does not significantly improve outcomes, but achieving OMT later can lead to better health results for heart failure patients.
Article Synopsis
- Cardiac resynchronization therapy (CRT) is beneficial for heart failure patients but many do not respond well, particularly those with malnutrition, which worsens their prognosis.
- A study evaluated the nutritional status of 302 heart failure patients using the Controlling Nutritional Status (CONUT) score, categorizing them into normal, mild malnutrition, and moderate-severe malnutrition.
- Findings revealed that higher CONUT scores indicated a greater risk of heart failure or death, while improving nutritional status post-CRT correlated with better health outcomes and significant heart remodeling.
Introduction: HF remains a frequent complication following MI and adversely affects prognosis. The objective of this study was to identify predictors of HF following MI and to design a risk score for its prediction.
Methods: Retrospective study of all consecutive patients admitted for MI.
Background: Malnutrition is common in hospitalized heart failure (HF) patients and predicts adverse outcomes. The relationship between nutritional status and outcomes in HF has been partially studied. Our aim was to determine the relationship between the nutritional status and the long-term prognosis in patients hospitalized for acute HF.
View Article and Find Full Text PDFDiscrepancy between stress electrocardiographic changes and nuclear myocardial perfusion defects in the prognostic assessment of patients with chest pain.
Rev Port Cardiol
October 2013
Objectives: The aim of the present study was to determine the long-term prognostic value provided by the exercise electrocardiographic (ECG) response to nuclear myocardial perfusion imaging (MPI) in the evaluation of patients with chest pain, focusing on patients with a discrepancy between the two tests.
Methods: A total of 1460 consecutive patients (777 female; 62.6 ± 11.
Walking beyond the GRACE (Global Registry of Acute Coronary Events) model in the death risk stratification during hospitalization in patients with acute coronary syndrome: what do the AR-G (ACTION [Acute Coronary Treatment and Intervention Outcomes Network] Registry and GWTG [Get With the Guidelines] Database), NCDR (National Cardiovascular Data Registry), and EuroHeart Risk Scores Provide?
JACC Cardiovasc Interv
November 2012
Objectives: This study sought to compare the in-hospital prognostic values of the original and updated GRACE (Global Registry of Acute Coronary Events) risk score (RS) and the AR-G (ACTION [Acute Coronary Treatment and Intervention Outcomes Network] Registry and the GWTG [Get With the Guidelines] Database) RS in acute coronary syndromes (ACS). To evaluate the utility of recalculating risk after percutaneous coronary intervention (PCI) with newer RS models (NCDR [National Cardiovascular Data Registry] and EHS [EuroHeart Score] RS).
Background: Defined in 2003, GRACE is among the most popular systems of risk stratification in ACS.