Publications by authors named "Rosa Lama More"
Article Synopsis
- Hyperammonaemia is a serious metabolic issue that can lead to brain damage and death, often seen in small children due to genetic disorders but more commonly in adults as a result of liver disease, medications, or dehydration.
- The protocol aims to guide healthcare professionals on how to treat this condition effectively by emphasizing close monitoring, nutritional support, and timely use of medications and treatments.
- It recommends starting haemodialysis for ammonia levels above certain thresholds: >200−350 µmol/L for children under 18 months and >150−200 µmol/L for older patients.
Article Synopsis
- The study aimed to evaluate how reliable two nutritional screening tools (STRONGkids and STAMP) are in identifying malnutrition risk in children admitted to hospitals, through observations by both nutrition experts and nonexperts.
- Involving 223 pediatric patients, the results showed good agreement between expert and nonexpert staff, with both groups identifying similar proportions of high-risk patients using the tools.
- The findings suggest that STRONGkids and STAMP can effectively guide nutritional screening regardless of the observer's expertise, with higher risk scores correlating with longer hospital stays.
Background: Isovaleric aciduria (IVA), propionic aciduria (PA) and methylmalonic aciduria (MMA) are inherited organic acidurias (OAs) in which impaired organic acid metabolism induces hyperammonaemia arising partly from secondary deficiency of N-acetylglutamate (NAG) synthase. Rapid reduction in plasma ammonia is required to prevent neurological complications. This retrospective, multicentre, open-label, uncontrolled, phase IIIb study evaluated the efficacy and safety of carglumic acid, a synthetic structural analogue of NAG, for treating hyperammonaemia during OA decompensation.
View Article and Find Full Text PDFBackground: Advances in the diagnosis and treatment of urea cycle disorders (UCDs) have led to a higher survival rate. The purpose of this study is to describe the characteristics of patients with urea cycle disorders in Spain.
Methods: Observational, cross-sectional and multicenter study.
Unlabelled: Malnutrition among hospitalized patients has clinical implications and is associated with adverse outcomes: depression of the immune system, impaired wound healing, muscle wasting, longer length of stay, higher costs and increased mortality. Although the rate of malnutrition in hospitalized children varies in different studies, it seems to be lower than in adult population. Nevertheless, this is a population that has a higher risk of developing malnutrition during hospital stay.
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