[Adiponectin levels in perimenopause].

Background: Adiponectin is an hormone produced exclusively in adipose tissue, that actively acts in carbohydrate and fat regulation processes.

Objective: To determine adiponectin levels in a women's group.

Patients And Method: Transversal study in 22 amenorrheal women with climacteric symptoms, and without estrogen therapy.

Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in rat.

Hyperglycemia is associated with metabolic disturbances affecting cell redox potential, particularly the NADPH/NADP+ ratio and reduced glutathione levels. Under oxidative stress, the NADPH supply for reduced glutathione regeneration is dependent on glucose-6-phosphate dehydrogenase. We assessed the effect of different hyperglycemic conditions on enzymatic activities involved in glutathione regeneration (glucose-6-phosphate dehydrogenase and glutathione reductase), NADP(H) and reduced glutathione concentrations in order to analyze the relative role of these enzymes in the control of glutathione restoration.