Generation of mesenchymal stromal cells from urine-derived iPSCs of pediatric brain tumor patients.

Human induced pluripotent stem cells (iPSCs) provide a virtually inexhaustible source of starting material for next generation cell therapies, offering new opportunities for regenerative medicine. Among different cell sources for the generation of iPSCs, urine cells are clinically relevant since these cells can be repeatedly obtained by non-invasive methods from patients of any age and health condition. These attributes encourage patients to participate in preclinical and clinical research.

Hypoparathyroidism after thyroidectomy: A 20-year experience at a children's hospital.

Introduction: Hypoparathyroidism (HP) is the most common complication of total thyroidectomy and can be an emergency.

Objectives: To describe the prevalence of HP after total thyroidectomy in children under 14 years of age, the variables related to its appearance and its clinical expression.

Patients And Methods: Retrospective study at a children's hospital in the last 20 years.

Hypoparathyroidism after thyroidectomy: A 20-year experience at a children's hospital.

Introduction: Hypoparathyroidism (HP) is the most common complication of total thyroidectomy and can be an emergency.

Objectives: To describe the prevalence of HP after total thyroidectomy in children under 14 years of age, the variables related to its appearance and its clinical expression.

Patients And Methods: Retrospective study at a children's hospital in the last 20 years.

Three-dimensional printed model of bilateral Wilms tumor: A useful tool for planning nephron sparing surgery.

Nephron sparing surgery (NSS) is increasingly utilized to treat patients with bilateral Wilms tumor. We present a case of NSS planning using a three-dimensional computerized and printed model of both kidneys with anatomical structures of interest (parenchyma, renal pelvis, major calyx, renal artery, renal vein, and tumor). This model allowed a better understanding of the anatomic relation between the tumor and the normal kidney on each side, improving the surgical planning and the preoperative discussion with the patient's family.

Multinodular goiter in children: treatment controversies.

Background: Multinodular goiter (MG) is very common in adults. MG may occur in children in some exceptional circumstances. The objective of this study was to examine two cases of MG in children who relapsed soon after surgery and to discuss the treatment options in pediatric ages.

Intraoperative parathyroid hormone monitoring in neonatal severe primary hyperparathyroidism.

Neonatal severe primary hyperparathyroidism presents in the first days of life with severe life-threatening hypercalcemia. It is associated with an inactivating homozygous mutation of the calcium sensing receptor gene. Total parathyroidectomy is the treatment of choice, so the surgeon must identify all the parathyroid tissue, including supernumerary and ectopic glands.

Differential diagnosis and management of liver tumors in infants.

During the first year of life, most of the liver neoplasms are benign in origin, but some of these histologically benign lesions may be challenging in their management. Although most hepatic hemangiomas can be safely observed until involution is documented, some patients will need treatment due to progressive hepatomegaly, hypothyroidism and/or cardiac failure. Large mesenchymal hamartomas may require extensive hepatic resection and an appropriate surgical plan is critical to obtain good results.