Publications by authors named "Rosa A Veguilla"
Using iBiology as a Tool for Undergraduate Neuroscience Education.
J Undergrad Neurosci Educ
December 2018
This article presents iBiology, a free website that produces online resources for science education. iBiology develops material that can be used in preparation prior to lecture or as part of the curriculum and includes videos (research talks and technical videos), flipped classroom curriculum, and professional development courses. Neuroscience educators can find videos of leading scientists explaining crucial experiments in their field or demonstrating critical laboratory techniques like fluorescence microscopy.
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- The study focuses on how microRNA (miRNA) genes, particularly miR-211, are processed from introns of larger genes and how this process affects gene splicing.
- Key findings show that the RNase III enzyme Drosha is crucial for both the formation of mature miR-211 and for facilitating the splicing of associated exons in the melastatin gene.
- Mutations in specific splice sites highlighted a connection between spliceosome assembly and miRNA biogenesis, indicating that splicing factors influence the expression of intronic miRNAs.
DICER is a central regulator of microRNA maturation. However, little is known about mechanisms regulating its expression in development or disease. While profiling miRNA expression in differentiating melanocytes, two populations were observed: some upregulated at the pre-miRNA stage, and others upregulated as mature miRNAs (with stable pre-miRNA levels).
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