Hemorrhagic fever in Cambodia is caused by dengue viruses: evidence for transmission of all four serotypes.

Hemorrhagic fever (HF) has been widespread in Cambodia and thought to be due to dengue virus although laboratory confirmation has been lacking. Between 1980 and 1995, 49,420 cases of HF and 3,032 deaths were reported. Cases increased during this period; large epidemics of HF occurred every two to three years.

The CAT/CLAMS assessment for early intervention services. Clinical Adaptive Test/Clinical Linguistic and Auditory Milestone Scale.

The Clinical Adaptive Test/Clinical Linguistic and Auditory Milestone Scale (CAT/CLAMS) is a relatively new test of language, problem-solving abilities, and visual-motor skills for children ages 0 to 36 months of age. This instrument was compared to the Bayley Mental Developmental Index (MDI), the generally accepted standard of infant developmental tests. This study evaluates 328 normal children tested in infancy and then at 18 and 30 months of age.

Aseptic meningitis in infants < 2 years of age: diagnosis and etiology.

Standard virologic methods were used to characterize the relative contribution of each of the enterovirus classes to the etiology of aseptic meningitis during a prospective study of this disease among children < 24 months old. Viruses were isolated in cell culture from 164 (60%) of 274 cases identified over 5 years and in newborn mice from only 2 of 104 remaining cell culture-negative cases. Serologic tests identified the viral pathogen in 3 additional cases.

Aseptic meningitis in infants younger than 2 years of age: acute illness and neurologic complications.

Objective: We report the clinical features and cerebrospinal fluid (CSF) laboratory values for 277 children younger than 24 months of age with aseptic meningitis who were prospectively evaluated at three Baltimore hospitals between July 1986 and December 1990. A major objective was to define the incidence, etiology, and outcome of neurologic complications occurring during the acute illness.

Methods: Cases were identified by surveillance in the ambulatory care departments of each of the three hospitals, pertinent historical and clinical data were obtained by interview of the parents and by review of the medical records, initial CSF laboratory values were recorded, and appropriate specimens were submitted to determine the viral etiology.