Essential oil and aqueous extract of basil (Ocimum basilicum) in the diet of pacu (Piaractus mesopotamicus).

This study aimed to evaluate the effects of Ocimum basilicum supplementation in the diet for Piaractus mesopotamicus regarding productive performance, intestinal morphology, muscle residue, and hematological changes after simulated transport stress. Juvenile (23 g±0.08, n = 180) were stocked into 300-L tanks in three treatments and six replicates each: a control diet (not supplemented), a diet with 0.

Draft genome assemblies of three strains isolated from catheterized urine samples from the same male participant over the course of 6 months.

is a newly identified species within the complex. Here, we present the draft genome sequence of three strains that were isolated from catheterized urine samples collected from a participant in a longitudinal study over ~6 months.

Electrical carotid sinus nerve stimulation attenuates experimental colitis induced by acetic acid in rats.

Aims: The carotid bodies are sensors that detect physiological signals and convey them to the central nervous system, where the stimuli are processed inducing reflexes through efferent pathways. Recent studies have demonstrated that electrical stimulation of the carotid sinus nerve (CSN) triggers the anti-inflammatory reflex under different conditions. However, whether this electrical stimulation attenuates colitis was never examined.

Promoting plant-based eating in meat-centric meal contexts: a field study.

Objective: Shifting from meat-centric to plant-rich diets may help to enable healthier and more sustainable food systems. Here we present the results of a 1-week intervention to promote plant-based eating in a meat-centric food context (i.e.

Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma.

Pilocytic astrocytoma (PA), the most common pediatric brain tumor, is driven by aberrant mitogen-activated protein kinase signaling most commonly caused by BRAF gene fusions or activating mutations. While 5-year overall survival rates exceed 95%, tumor recurrence or progression constitutes a major clinical challenge in incompletely resected tumors. Here, we used similarity network fusion (SNF) analysis in an integrative multi-omics approach employing RNA transcriptomic and mass spectrometry-based proteomic profiling to molecularly characterize PA tissue samples from 62 patients.

How to enable healthier and more sustainable food practices in collective meal contexts: A scoping review.

Collective meal contexts such as restaurants, cafeterias and canteens can help accelerate transitions to healthier and more sustainable diets. However, evidence from intervention studies on these contexts lacks integration. This scoping review aimed to map determinants of dietary change in collective meal contexts across multiple settings, interventions, target groups, and target behaviors.

Insights into parents' and teachers' support for policies promoting increased plant-based eating in schools.

Global environmental and public health challenges related to current food systems call for large-scale shifts towards increasingly plant-based diets, especially in Western meat-centric societies. School meal systems can play a role in these changes due to their widespread prevalence and multi-sectoral impact. However, there is a lack of evidence about how adults involved in the school meals system perceive school-based pro-environmental food policies, which limits the ability to align those policies with the needs and expectations of the school community.

Medulloblastoma Development in a Patient with a Constitutional Balanced t(5;22)(q35.1;q11.2) Involving the Gene.

Neurofibromatosis type 2 (NF2) is a brain tumor predisposing syndrome caused by inactivating alterations of the gene mapped at chromosome 22q. Currently, no genetic information exists on medulloblastomas occurring in NF2 patients. We herein report on the genetic alterations observed in a girl in which the gene was de novo altered due to a constitutional translocation: t(5;22)(q35.

Australian Pelvic Floor Questionnaire: translation, cultural adaptation, and validation.

Introduction And Hypothesis: The aim was to translate, culturally adapt, and validate the APFQ (Australian Pelvic Floor Questionnaire) for the population of Brazilian pregnant and postpartum women.

Methods: The translation and validation of the APFQ were performed according to Beaton's guideline recommendations, with a sample of 150 patients (75 pregnant, 75 postpartum). Cronbach's alpha assessed the scale's internal consistency and reproducibility with the intraclass correlation coefficient (ICC).

Design of new hydrolyzed collagen-modified magnetic nanoparticles to capture pathogens.

Enrichment and diagnosis tools for pathogens currently available are time consuming, thus the development of fast and highly sensitive alternatives is desirable. In this study, a novel approach was described that enables selective capture of bacteria expressing hydrolyzed collagen-binding adhesins with hydrolyzed collagen-coated magnetic nanoparticles (MNPs). This platform could be useful to shorten the time needed to confirm the presence of a bacterial infection.

Mutations in Diffuse Gliomas: An Update on Molecular Stratification, Prognosis, Recurrence, and Aggressiveness.

Introduction: is one of the most mutated oncogenes in solid tumors. In breast cancer (ER-positive, HER2-negative), these events represent a predictive biomarker of response to alpelisib. In glioblastomas (GBM), mutations were described as early constitutive events.

PERCEPTION OF HARASSMENT AMONG FEMALE SURGEONS.

Introduction: the attraction of women by Surgery has always existed. Although Surgery has been considered a specialty for men, several women chose it, despite gender bias issues that have persisted over many years. Several obstacles have impacted the practice of women surgeons, leading them to abandon the profession, while others, perhaps bearers of a stronger spirit, managed to overcome them, and won.

Oral insulin delivery: utopia, currently possible or a near reality?

Diabetes is still one of the main diseases worldwide due to its high incidence, prevalence and, unfortunately, very high mortality. Type 1 diabetes (and in some other types) is generally controlled by exogenous insulin. Several attempts of oral insulin administration to humans have been done so far.

The impact of prolonged frozen storage on the preparation quality of bird skins and skeletons in zoological collections.

Specimens from zoological collections play a pivotal role in improving scientific knowledge in many natural science disciplines. To guarantee an optimum state of conservation and ensure their usefulness, the preparation process employed is crucial. Skins and skeletons are key elements in vertebrate scientific collections and, ideally, are prepared from recently deceased animals; however, specimens are often stored in a frozen state for a long time (years) prior to preparation.

Aprosopia/holoprosencephaly in a stillborn puppy: when the face predicts the brain.

In a litter of three puppies, one was stillborn and had facial and brain defects. Fusion of the maxilla and mandible and absence of the face were observed. The forebrain (telencephalon and the diencephalon) was reduced in size and fused, and the telencephalic longitudinal fissure, olfactory bulbs, and optic nerves were absent (Figures 6 and 7).

Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial.

Acute respiratory distress syndrome (ARDS) in COVID-19 is associated with high mortality. Mesenchymal stem cells are known to exert immunomodulatory and anti-inflammatory effects and could yield beneficial effects in COVID-19 ARDS. The objective of this study was to determine safety and explore efficacy of umbilical cord mesenchymal stem cell (UC-MSC) infusions in subjects with COVID-19 ARDS.

Age-Related Compensation Mechanism Revealed in the Cortical Representation of Degraded Speech.

Older adults understand speech with comparative ease in quiet, but signal degradation can hinder speech understanding much more than it does in younger adults. This difficulty may result, in part, from temporal processing deficits related to the aging process and/or high-frequency hearing loss that can occur in listeners who have normal- or near-normal-hearing thresholds in the speech frequency range. Temporal processing deficits may manifest as degraded neural representation in peripheral and brainstem/midbrain structures that lead to compensation, or changes in response strength in auditory cortex.

A Brief Overview of the Oral Delivery of Insulin as an Alternative to the Parenteral Delivery.

Diabetes mellitus greatly affects the quality of life of patients and has a worldwide prevalence. Insulin is the most commonly used drug to treat diabetic patients and is usually administered through the subcutaneous route. However, this route of administration is ineffective due to the low concentration of insulin at the site of action.

Novel and revisited approaches in nanoparticle systems for buccal drug delivery.

The buccal route is considered patient friendly due to its non-invasive nature and ease of administration. Such delivery route has been used as an alternative for the delivery of drugs that undergo first-pass metabolism or are susceptible to pH and enzymatic degradation, such as occurs in the gastrointestinal tract. However, the drug concentration absorbed in the buccal mucosa is often low to obtain an acceptable therapeutic effect, mainly due to the saliva turnover, tongue and masticatory movements, phonation, enzymatic degradation and lack of epithelium permeation.

Clinical insights gained by refining the 2016 WHO classification of diffuse gliomas with: EGFR amplification, TERT mutations, PTEN deletion and MGMT methylation.

Background: Significant advances in the molecular profiling of gliomas, led the 2016 World Health Organization (WHO) Classification to include, for the first-time, molecular biomarkers in glioma diagnosis: IDH mutations and 1p/19q codeletion. Here, we evaluated the effect of this new classification in the stratification of gliomas previously diagnosed according to 2007 WHO classification. Then, we also analyzed the impact of TERT promoter mutations, PTEN deletion, EGFR amplification and MGMT promoter methylation in diagnosis, prognosis and response to therapy in glioma molecular subgroup.

Effects of Age, Cognition, and Neural Encoding on the Perception of Temporal Speech Cues.

Older adults commonly report difficulty understanding speech, particularly in adverse listening environments. These communication difficulties may exist in the absence of peripheral hearing loss. Older adults, both with normal hearing and with hearing loss, demonstrate temporal processing deficits that affect speech perception.

Establishment and characterization of a new patient-derived anaplastic thyroid cancer cell line (C3948), obtained through fine-needle aspiration cytology.

Purpose: Anaplastic thyroid cancer (ATC) is among the most aggressive and unresectable tumors, presenting a bad prognosis. A better comprehension of the functional and molecular mechanisms behind the aggressiveness of this cancer, as well as new biomarkers for aggressiveness, prognosis, and response to therapy are required. However, owing to their irresectability, ATC tissue is not always accessible.

Phytosomes with Persimmon ( L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability.

Persimmon ( L.), a fruit rich in phenolic compounds (PCs), has been considered effective in mitigating oxidative damage induced by an excess of reactive oxygen species. Due to large molecular weight and intrinsic instability in some physiological fluids, PCs' passage through biological membranes is very limited.

Age Effects on Neural Representation and Perception of Silence Duration Cues in Speech.

Purpose Degraded temporal processing associated with aging may be a contributing factor to older adults' hearing difficulties, especially in adverse listening environments. This degraded processing may affect the ability to distinguish between words based on temporal duration cues. The current study investigates the effects of aging and hearing loss on cortical and subcortical representation of temporal speech components and on the perception of silent interval duration cues in speech.