Concerns of patients with inflammatory bowel disease: results from a clinical population.

Objective: The impact of chronic illness is influenced not just by physical symptoms but also by psychosocial factors. The aim of this study was to determine the concerns of inflammatory bowel disease (IBD) patients in a clinical sample, if concerns differ between patients from varied clinical and demographic variables, and if concerns influence well-being beyond the influence of physical symptoms.

Methods: Subjects (n = 259) completed a validated measure of concerns specific to IBD and provided demographic and disease-related information.

Concerns of patients with inflammatory bowel disease: a review of emerging themes.

Idiopathic, chronic inflammatory bowel disease (IBD) refers to two diseases-ulcerative colitis (UC) and Crohn's disease (CD). Despite an abundant literature discussing the pathophysiology and treatment of these diseases, little if any empirical studies have focused on patients' subjective experiences with their diseases. The purpose of this paper was to identify and discuss the concerns of individuals with IBD and to suggest that the integration of concerns in clinical management is necessary for a comprehensive understanding of these chronic and debilitating diseases.

Influence of sex and disease on illness-related concerns in inflammatory bowel disease.

Unlabelled: Identifying the normal concerns of people with ulcerative colitis and Crohn's disease (CD) facilitates a comprehensive approach to their medical care. Clinically, it can be easily appreciated that the concerns of men and women with inflammatory bowel disease (IBD) may differ and that this may have a substantial impact on both coping and treatment decisions. However, sex differences have received little empirical study.

Health-related concerns of people who receive psychological support for inflammatory bowel disease.

Background: People with inflammatory bowel disease (IBD) cope with a number of disease-specific concerns, which may result in referrals for supportive counselling.

Objective: To determine differences between the health-related concerns of people with IBD who seek counselling or are referred for psychiatric assessment and those who have no recent contact with counselling or psychiatry.

Methods: Forty-five consecutive patients with IBD referred for psychiatric consultation and 31 IBD out-patients who had recent counselling were compared with 190 IBD out-patients at the same hospital with no recent history of counselling.

Long-term evaluation of postorchiectomy radiotherapy for stage II seminoma.

Purpose: To determine survival, long-term tumor control, and the effects of irradiation for stage II seminoma.

Materials And Methods: Forty-five patients with stage II testicular seminoma were treated between 1966 and 1989. There were 31 patients with stage IIA disease and 14 with stage IIB disease.

Long-term evaluation of postorchiectomy irradiation for stage I seminoma.

Purpose: To determine the late clinical effects of irradiation in stage I seminoma.

Materials And Methods: From 1966 to 1991, 104 patients with stage I seminoma were treated and followed up. After inguinal orchiectomy, all underwent megavoltage infradiaphragmatic irradiation through a "hockey stick" field encompassing the periaortic and ipsilateral iliac lymph nodes (30 Gy in 1.

Lack of synergistic feeding enhancement by systemic clonidine and 8-OH-DPAT.

To expand on recent suggestions that brain alpha 2-adrenergic and serotonergic systems may interact in their controls over feeding, three experiments were conducted to determine if combining clonidine and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) injections subcutaneously might produce exponential feeding enhancements greater than responses elicited by either agent alone. Ad lib fed adult male rats were tested in 2 x 2 drug designs in all studies. In Experiment 1, 30 micrograms/kg clonidine reliably enhanced feeding over a 6-hr test period.

Effects of intracisternal vs. intrahypothalamic 5,7-DHT on feeding elicited by hypothalamic infusion of NE.

A variety of evidence has led to suggestions that brain serotonin (5-HT) and norepinephrine (NE) interact within the medial hypothalamus to control food intake. To test the possibility that chronic decrements in 5-HT might enhance NE-induced feeding, adult male rats were prepared with permanently indwelling cannulae aimed at the paraventricular nucleus (PVN), then received either intracisternal (IC) or PVN injections of the 5-HT neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT) vs. its vehicle, 1% ascorbic acid.

Effects of systemic 8-OH-DPAT on the feeding induced by hypothalamic NE infusion.

Past research suggests that activating brain serotonin (5-hydroxytryptamine or 5-HT) systems can inhibit feeding induced by activating brain norepinephrine (NE) systems. To explore this interaction more fully, we tested the capacity of the endogenous 5-HT release inhibitor, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), to enhance feeding stimulated by infusing NE into the medial hypothalamus. All experiments were conducted using ad lib-fed adult male rats with indwelling cannulae aimed at the paraventricular nucleus (PVN).