Plasma protein glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes.

Introduction: Although associations of total plasma glycome (TPNG) with type 2 diabetes have been reported, little is known on the role of TPNG in type 2 diabetes complications, a major cause of type 2 diabetes-related morbidity and mortality. Here, we assessed TPNG in relation to type 2 diabetes complications in subsamples of two Dutch cohorts using mass spectrometry (n=1815 in DiaGene and n=1518 in Hoorn Diabetes Care System).

Research Design And Methods: Blood plasma samples and technical replicates were pipetted into 96-well plates in a randomized manner.