A New bis(rhodamine)-Based Colorimetric Chemosensor for Cu.

A novel sensor (RD) bearing rhodamine B and 4-tert-Butyl phenol unit have been designed and synthesized using microwave irradiation. The sensor allows selective detection of Cu by forming absorptive complex and trigger the formation of highly colored ring-open spirolactam. The recognition ability of the sensor was investigated by absorbance, Job's plot, infrared (IR) and time dependent-density functional theory (TD-DFT) calculations.

A rhodamine-based fluorescent sensor for selective detection of Cu in aqueous media: synthesis and spectroscopic properties.

Two new chemosensors, rhodamine B derivative bearing 3-formyl-6-nitrochromone ( ) and 3-formyl-6-methylchromone ( ) units were designed and synthesized using microwave irradiation for the selective detection of Cu in aqueous media. Copper triggers the formation of highly fluorescent ring-open spirolactam. The fluorescence intensity was remarkably increased upon the addition of Cu within a minute, while the other metal ions caused no significant effect.

Two colorimetric fluorescent turn-on chemosensors for detection of Al and N : Synthesis, photophysical and computational studies.

Two new rhodamine derivative L and L bearing 2-methoxy-1-naphthaldehyde and 5-bromo-3-methoxy salicylaldehyde units were designed and synthesized using microwave-assisted organic synthesis and utilized towards sequential fluorescence detection of aluminum ion (Al ) and azide (N ) in aqueous acetonitrile solution. Aluminum ion (Al ) triggers the formation of highly fluorescent ring-open spirolactam. The fluorescence and colorimetric response of the L -Al and L -Al complexes were quenched by the addition of N , which extracting the Al from the complexes and turn-off the sensors, confirming that the recognition process is reversible.

The Effects of Synthesized Rhenium Acetylsalicylate Compounds on Human Astrocytoma Cell Lines.

Purpose: Because of the scarcity of suitable brain cancer drugs, researchers are frantically trying to discover novel and highly potent drugs free of side effects and drug-resistance. Rhenium compounds are known to be nontoxic and exhibit no drug resistance. For that reason, we have developed a series of novel rhenium acetylsalicylato (RAC or ASP) complexes to test their cytotoxicity on brain cancer cells.

Unprecedented anticancer activities of organorhenium sulfonato and carboxylato complexes against hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells.

Cisplatin and other metal-based drugs often display side effects and tumor resistance after prolonged use. Because rhenium-based anticancer complexes are often less toxic, a novel series of organorhenium complexes were synthesized of the types: XRe(CO)Z (X = α-diimines and Z = p-toluenesulfonate, 1-naphthalenesulfonate, 2-naphthalenesulfonate, picolinate, nicotinate, aspirinate, naproxenate, flufenamate, ibuprofenate, mefenamate, tolfenamate, N-acetyl-tryptophanate), and their biological properties were examined. Specifically, in hormone-dependent MCF-7 and hormone-independent triple-negative MDA-MB-231 breast cancer cells, the p-toluenesulfonato, 1-naphthalenesulfonato, 2-naphthalenesulfonato, picolinato, nicotinato, acetylsalicylato, flufenamato, ibuprofenato, mefenamato, and N-acetyl-tryptophanato complexes were found to be far more potent than conventional drug cisplatin.

DNA-binding and cytotoxic efficacy studies of organorhenium pentylcarbonate compounds.

Seven organorhenium pentylcarbonate compounds (PC1-PC7) have been synthesized. DNA-binding studies of the PC-series compounds using electronic spectroscopy and gel electrophoresis suggest that the compounds presumably bind to DNA in an intercalative mode. The intrinsic binding constants for PC4, PC6, and PC7 were found to be 1.