Acute neuromuscular and hormonal responses to 20 versus 40% velocity loss in males and females before and after 8 weeks of velocity-loss resistance training.

New Findings: What is the central question of this study? Do males and females differ in fatiguability during dynamic loadings, and what are the acute neuromuscular and hormonal responses to 20 versus 40% velocity-loss resistance loadings? How does an 8-week velocity-loss resistance training period modify acute neuromuscular and hormonal responses in males and females? What is the main finding and its importance? Using resistance training methods that regulated the within-set fatigue limit, males appeared to be more susceptible to fatigue than females before the training period. This between-sex difference was diminished after training. The predominant mechanisms of fatigue from 20 and 40% velocity-based resistance training appear to be within the musculature.