Project HCV Connect: Using a County Surveillance Registry to Link Hepatitis C Virus-Infected Residents to Cure-Los Angeles County, April 2023 to March 2024.

Los Angeles County has a high prevalence of chronic hepatitis C virus (HCV) infection, but resources and infrastructure to notify and increase treatment uptake among county residents are absent. Through an innovative academic-public partnership, we developed a linkage-to-cure program utilizing the Department of Public Health's HCV surveillance registry. Case workers contacted reported cases via phone, to offer education, and treatment referral.

Primary Thyroid Tuberculosis Diagnosed with CBNAAT.

Tuberculosis is a common disease in India but even then Primary tuberculosis of Thyroid gland is an extremely rare clinical scenario. Diagnosis of this rare disease requires very high level of clinical suspicion as the clinical features have no distinct characteristics and usually mimic with bacterial thyroiditis, thyrotoxicosis, thyroid carcinoma, lymphoma etc. Historically most of patients were diagnosed through histopathology in post operative thyroidectomy specimens.

EXPRESS: In Silico Exploration of Bioactive Secondary Metabolites with Anesthetic Effects on Sodium Channels Nav 1.7, 1.8, and 1.9 in Painful Human Dental Pulp.

Aim: To investigate the efficacy of medicinal plant bioactive secondary metabolites as inhibitors of voltage-gated sodium channels (Nav1.7, Nav1.8, and Nav1.

Monitoring and risk assessment for pesticide residues in vegetables, soil, and water in Haryana, India.

The present study was conducted with the aim to identify estimates and risk assessment for the pesticide residue present in vegetables, soil, and water in Haryana, India. In the present study, environmental monitoring of commonly sprayed 161 pesticides was done using liquid chromatography-tandem mass spectrometry and gas chromatography-tandem mass spectrometry for 102 vegetables, 46 soil, and 50 water samples collected from four districts in Haryana, India. A total of 198 samples were analyzed for the presence of pesticide residue and the measured pesticide concentrations were compared with the Maximum Residue Limit (MRL) set by the Food Safety and Standards Authority of India (FSSAI) and European regulations.

Elucidating diagnostic efficacy and safety of the procedure: cryobiopsy of endobronchial lesions with a flexible bronchoscope.

When compared to conventional forceps biopsy, the use of a flexible cryoprobe allows for the sampling of endobronchial lesions, yielding well-preserved, circumferential, and substantial specimens, resulting in a higher diagnostic yield, as demonstrated in multiple studies. We evaluated the utility of cryobiopsy in the diagnosis of endobronchial lesions, as well as its safety profile in this study. This retrospective study included 200 patients who underwent cryobiopsy for bronchoscopically visible endobronchial lesions between March 2016 and July 2022.

Giant Parathyroid Adenoma Causing Dyspnea: A Rare Clinical Presentation.

Primary hyperparathyroidism is an endocrine disorder with muti-system involvement. The clinical condition is dealt by multi-speciality department. Parathyroid adenoma is the principal cause of primary hyperparathyroidism.

The infiltration of microplastics in human systems: Gastrointestinal accumulation and pathogenic impacts.

Microplastic particles have become ubiquitous in various ecosystems due to a drastic increase in plastic use and its consequent litter. The biological effects of these plastic particles on aquatic fauna are well-documented. However, the study of their accumulation and subsequent impact on terrestrial flora and fauna is in its initial stages.

HIV-Induced Sialoglycans on Infected Cells Promote Immune Evasion from Myeloid Cell-Mediated Killing.

Sialic acid-containing glycans (sialoglycans) on pathological cells interact with Siglecs, glyco-immune checkpoint receptors expressed on myeloid cells such as monocytes and neutrophils. This interaction suppresses the cytotoxic functions of these immune cells. We show that HIV infection reprograms the glycosylation machinery of infected cells to increase the expression of specific sialoglycan ligands for Siglecs-3, -7, and -9.

Perinatal Nicotine Exposure Disrupts Hematopoietic Stem Cell Development and Elevates Influenza Susceptibility in Adulthood.

Tobacco use during pregnancy has many deleterious health consequences for not only the smoking mother, but also on the unborn fetus. Children of smoking mothers are reported to have higher frequency and severity of respiratory diseases later in life; however, the mechanisms driving this increased vulnerability are not clearly understood. One potential cause of increased disease susceptibility is an altered immune system, originating in epigenetically maladaptive hematopoietic stem cells (HSCs).

An easily synthesizable naphthalene-based sensing platform for Al and Zn ions: theoretical insights and live cells imaging.

A new naphthalene-derived Schiff base probe, 1-((2-(diphenylphosphino)ethylimino)methyl)naphthalen-2-ol (HL), has been demonstrated for fluorometric detection of Al and Zn ions. HL was characterized by elemental analysis, FT-IR, NMR, UV-Vis, fluorescence, and ESI-MS analyses. It exhibited high sensitivity and selectivity toward Al and Zn ions in a semi-aqueous medium (CHCN-HO; 4 : 1, v/v), remaining unaffected by other competing metal ions.

Radiation stability of two extraction chromatography resins containing aza-crown-based diglycolamides used for Am(III) uptake.

The radiolytic stability of two extraction chromatography resins with multiple diglycolamide arms was investigated by exposing them to gamma radiation and carrying out uptake studies of Am(III) from acidic feeds. The resins contained aza-crown-based diglycolamide (DGA) ligands, viz., triaza-9-crown-3-N,N',N"-trisdiglycolamide (TAM-3-DGA) and tetraaza-12-crown-4-N,N',N",N'"-tetrakisdiglycolamide (TAM-4-DGA), where the DGA moieties were grafted to the 'N' atoms of the macrocyclic ring.

Self-referencing surface plasmon sensor for resolution enhancement.

In this paper, a self-referencing evanescent field sensor based on surface plasmon resonances is designed and fabricated. The sensor is based on sub-wavelength two-dimensional gold gratings and is optimized to detect changes in the surrounding refractive index for a water-like material. The sensor has a dedicated mode for self-referencing, which is isolated from the surrounding environment and can be used to correct errors due to temperature variations.

Electrochemical nanosensors: Revolutionizing vitamin detection.

Electrochemical nanosensors offer remarkable capabilities for precise and selective vitamin detection, with transformative implications for healthcare, nutrition, and food industry quality control. Nanotechnology advancements have facilitated the creation of nanoscale sensors with customized properties, enhancing the efficacy of detecting vitamins. Materials such as gold nanoparticles, carbon nanotubes, and quantum dots have been modified to display remarkable sensitivity and specificity for distinct vitamins.

Cognitive deficit identified via pre-operative patient reported outcome measures is a predictor for post-operative health care utilization in gynecologic oncology patients.

Objective: To determine if preoperative Patient-Reported Outcome Measures (PROMs) can be used to predict post-operative health care utilization in gynecology oncology patients.

Methods: A retrospective study was performed after Institutional Review Board approval. PROMs were collected pre-operatively from all patients undergoing surgery for gynecologic malignancy between 1/1/18 and 9/1/19 at a tertiary academic medical center.

The root-derived syringic acid and shoot-to-root phytohormone signaling pathways play a critical role in preventing apple scab disease.

Apple scab is a serious disease that has a huge economic impact. While some cultivars of apple are scab-resistant, most are not. Growing research has suggested that root-derived metabolites play a vital role in conferring resistance to aboveground pathogens through the long-distance signaling system between shoot and root.

Prevalence of pediatric and adolescent epilepsy in India: A systematic review and meta-analysis.

Introduction: Epilepsy is a widespread neurological disorder that affects millions of people worldwide, with a large proportion of cases emerging in childhood. Many children with epilepsy in low and middle-income countries, such as India, encounter obstacles to care despite effective treatments, which add to the treatment gap.

Methodology: A systematic review and meta-analysis was conducted in accordance with PRISMA guidelines.

Next-generation approach to skin disorder prediction employing hybrid deep transfer learning.

Introduction: Skin diseases significantly impact individuals' health and mental wellbeing. However, their classification remains challenging due to complex lesion characteristics, overlapping symptoms, and limited annotated datasets. Traditional convolutional neural networks (CNNs) often struggle with generalization, leading to suboptimal classification performance.

Remibrutinib in Chronic Spontaneous Urticaria.

Background: Chronic spontaneous urticaria is an idiopathic syndrome defined by recurring itch, hives, or angioedema (or a combination of these symptoms) for more than 6 weeks. Remibrutinib, an oral, highly selective Bruton's tyrosine kinase inhibitor, showed efficacy and favorable safety in phase 2b trials. Data from phase 3 trials are needed.

Evolving Landscape of Emerging Virus Diagnosis: Challenges and Innovations.

Emerging and re-emerging viruses (like Spanish flu, SARS-CoV-2, etc.) have substantially impacted global public health since the early twentieth century. These outbreaks are unpredictable and novel viruses are difficult to understand due to emerging variations.

Recent advances in MXene nanozyme-based optical and electrochemical biosensors for food safety analysis.

The importance of nanotechnology is increasing every day in different fields and, especially, the application of nanomaterials has attracted considerable attention in food safety. Among different nanomaterials, MXenes, which are two-dimensional (2D) transition metal-based layered materials made of nitrides and carbides, have revolutionized various fields as a cutting-edge scientific discovery in nanotechnology. These materials have been widely used in the structure of biosensors and sensors due to their excellent metallic conductivity, mechanical stability, optical absorbance, good redox capability, and higher heterogeneous electron transfer rate.

Pain without presence: a narrative review of the pathophysiological landscape of phantom limb pain.

Phantom limb pain (PLP) is defined as the perception of pain in a limb that has been amputated. In the United States, approximately 30,000-40,000 amputations are performed annually with an estimated 2.3 million people living with amputations.

Neural Mechanisms of Malodor Masking: A Wearable EEG Study.

Olfactory neuroscience has uncovered much about the neural underpinnings of conscious olfactory evaluations, most particularly in relation to pleasantness. Past research have focused on how the brain responds to purely pleasant or unpleasant odors, leaving little known about the neural responses to the masking of known unpleasant stimuli (malodors) by pleasant stimuli. To address this, in the present study participants were exposed to malodor of high and low intensity, with and without a pleasant masking stimuli.

Improving inner speech decoding by hybridisation of bimodal EEG and fMRI data.

Decoding inner speech from the brain via the hybridisation of fMRI and EEG data is explored to investigate the performance benefits over unimodal models. Two different fusion approaches are examined: concatenation of probability vectors from unimodal fMRI and EEG machine learning models, and data fusion with feature engineering. Same-task inner speech data are recorded from four participants, and different processing strategies are compared and contrasted to previously-employed hybridisation efforts.