Publications by authors named "Roopa Kumari"

The availability of an effective vaccine does not equate to its use; its effectiveness primarily depends on vaccine acceptance by the targeted population. Despite the rapid development and widespread access to the COVID-19 vaccine, herd immunity is yet to be achieved, with vaccine hesitancy as a major barrier. This study sought to systematically assess the beliefs, attitudes, and acceptance towards COVID-19 vaccines, including factors contributing to vaccination hesitancy in the Eastern and Western Hemispheres.

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  • The study examines the effects of low vs. high vancomycin trough levels on clinical outcomes in adults with sepsis or gram-positive infections, moving away from the previously recommended dosage guidelines.
  • A systematic review and meta-analysis of 14 studies involving over 5,200 patients showed no significant links between vancomycin levels and various clinical outcomes like microbial clearance and ICU stay.
  • However, lower trough levels appeared to trend towards reduced treatment failure and were significantly associated with lower all-cause mortality rates.
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  • The systematic review and meta-analysis aimed to evaluate the effectiveness, safety, and tolerability of using urea to treat hyponatremia caused by SIADH, addressing previously raised concerns in the medical community.
  • The study analyzed existing observational research from multiple databases, focusing on patients with SIADH-related low sodium levels and including trials that measured outcomes like serum sodium concentration and any adverse effects from urea administration.
  • Results showed that urea treatment led to a significant improvement in serum sodium levels, particularly in more severe cases of hyponatremia, indicating it may be an effective treatment option despite some variability in outcomes.
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Introduction: Obesity is characterized by chronic low-grade inflammation. This study presents an updated systematic review and meta-analysis on the effect of caloric restriction (CR) and intermittent fasting (IF) on plasma inflammatory biomarkers (C-reactive protein [CRP], tumor necrosis factor [TNF]-alpha, and interleukin [IL]-6) in individuals with obesity/overweight compared with unrestricted or ad libitum feeding.

Methods: PubMed, Web of Science, and SCOPUS databases were searched for randomized controlled trials (RCTs) reporting inflammatory biomarkers after at least 8 weeks of intervention.

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Background: Catheter ablation and antiarrhythmic drug therapy are utilized for rhythm control in atrial fibrillation (AF), but their comparative effectiveness, especially with contemporary treatment modalities, remains undefined. We conducted a systematic review and meta-analysis contrasting current ablation techniques against antiarrhythmic medications for AF.

Methods: We searched PubMed, SCOPUS, Cochrane CENTRAL, and Web of Science until November 2023 for randomized trials comparing AF catheter ablation with antiarrhythmics, against antiarrhythmic drug therapy alone, reporting outcomes for > 6 months.

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  • A study was conducted to evaluate the effectiveness and safety of various vasopressors, like epinephrine and vasopressin, in patients who experienced cardiac arrest, focusing on clinical and mortality outcomes.
  • The analysis included 26 studies and found that epinephrine significantly improved survival rates to hospital discharge and the return of spontaneous circulation compared to a placebo, but did not show advantages in other outcomes like short-term survival or neurological function.
  • Combinations of vasopressors did not outperform epinephrine alone, though there was a slight improvement in survival to hospital admission with combined therapies.
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Introduction: Acute pancreatitis poses a significant health risk due to the potential for pancreatic necrosis and multi-organ failure. Fluid resuscitation has demonstrated positive effects; however, consensus on the ideal intravenous fluid type and infusion rate for optimal patient outcomes remains elusive.

Methods: A comprehensive literature search was conducted using PubMed, Embase, the Cochrane Library, Scopus, and Google Scholar for studies published between 2005 and January 2023.

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Background: In recent years, innovation in healthcare technology has significantly improved the efficiency of the healthcare system. Advancements have led to better patient care and more cost-effective services. The electronic medical record (EMR) system, in particular, has enhanced interoperability and collaboration across healthcare departments by facilitating the exchange and utilization of patient data.

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Background: The global use of kidney replacement therapy (KRT) has increased, mirroring the incidence of acute kidney injury and chronic kidney disease. Despite its growing clinical usage, patient outcomes with KRT modalities remain controversial. In this meta-analysis, we sought to compare the mortality outcomes of patients with any kidney disease requiring peritoneal dialysis (PD), hemodialysis (HD), or continuous renal replacement therapy (CRRT).

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Background: Females and ethnic minorities are underrepresented in the first and senior authorships positions of academic publications. This stems from various structural and systemic inequalities and discrimination in the journal peer-review process, as well as educational, institutional, and organizational cultures.

Methods: A retrospective bibliometric study design was used to investigate the representation of gender and racial/ethnic groups in the authorship of critical care randomized controlled trials in 12 high-impact journals from 2000 to 2022.

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Critical care practice has been embodied in the healthcare system since the institutionalization of intensive care units (ICUs) in the late '50s. Over time, this sector has experienced many changes and improvements in providing immediate and dedicated healthcare as patients requiring intensive care are often frail and critically ill with high mortality and morbidity rates. These changes were aided by innovations in diagnostic, therapeutic, and monitoring technologies, as well as the implementation of evidence-based guidelines and organizational structures within the ICU.

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Given the mortality risk in COVID-19 patients, it is necessary to estimate the impact of glycemic control on mortality rates among inpatients by designing and implementing evidence-based blood glucose (BG) control methods. There is evidence to suggest that COVID-19 patients with hyperglycemia are at risk of mortality, and glycemic control may improve outcomes. However, the optimal target range of blood glucose levels in critically ill COVID-19 patients remains unclear, and further research is needed to establish the most effective glycemic control strategies in this population.

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Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening systemic inflammatory disease. Multiple risk factors have been defined for the manifestation of HLH. While infection remains the top risk factor, having multiple surgical procedures has also been suggested as a potential risk factor for HLH.

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A composite material consisting of silver nanoparticles (Ag NPs) deposited on graphene oxide (GO) nanosheets is prepared by chemical reduction of Ag metal ions by sodium borohydride (NaBH4) in the presence of trisodium citrate acting as a stabilizing agent to prevent agglomeration of the nanoparticles. The synthesized GO/Ag NPs composite was characterized by UV/vis spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and transmission electron microscopy (TEM). TEM analysis confirmed a high density of Ag NPs on the GO nanosheets with a particle size range of 2-25 nm.

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