Is a wandering mind a novelty-seeking mind? The curious case of incubation.

The Novelty-Seeking Model can explain incubation's effect on creativity by assuming an adaptive decision threshold. During an impasse, the threshold for novelty becomes too high and biased to previous neural activity, hindering progress. Incubation "resets" this threshold through attentional decoupling, allowing for spontaneous ideas to emerge from subsequent mind wandering or other activities that attract attention, facilitating progress.

ERASE: a feasible early warning tool for elder abuse, developed for use in the Dutch emergency department.

Background: Elder abuse is a worldwide problem with serious consequences for individuals and society. To effectively deal with elder abuse, a timely identification of signals as well as a systematic approach towards (suspected) elder abuse is necessary. This study aimed to develop and test the acceptability and appropriateness of ERASE (EldeR AbuSE) in the emergency department (ED) setting.

The Push Forward in Rehabilitation: Validation of a Machine Learning Method for Detection of Wheelchair Propulsion Type.

Within rehabilitation, there is a great need for a simple method to monitor wheelchair use, especially whether it is active or passive. For this purpose, an existing measurement technique was extended with a method for detecting self- or attendant-pushed wheelchair propulsion. The aim of this study was to validate this new detection method by comparison with manual annotation of wheelchair use.

Commensurate and incommensurate 1D interacting quantum systems.

Single-atom imaging resolution of many-body quantum systems in optical lattices is routinely achieved with quantum-gas microscopes. Key to their great versatility as quantum simulators is the ability to use engineered light potentials at the microscopic level. Here, we employ dynamically varying microscopic light potentials in a quantum-gas microscope to study commensurate and incommensurate 1D systems of interacting bosonic Rb atoms.

The effect of regional transmural agreements on the information transfer of frail older patients.

Introduction: Frail older patients are at risk for many complications when admitted to the hospital. Multidisciplinary regional transmural agreements (RTA) in which guidelines were set concerning the information transfer of frail older patients might improve outcomes. We aim to investigate the effect of implementation of the RTA on the completeness of the information transfer of frail older patients when admitted to and discharged from the hospital.

Pre-stroke activities of daily living do not predict functional decline after stroke in a cohort of community dwelling older subjects at risk for vascular disease.

Background & Purpose: Pre-stroke impairment of activities of daily living (ADL) is considered a major determinant for functional outcome after stroke. However, findings are based on studies in stroke patients in which pre-stroke information is gathered retrospectively, with inherent risks of selection and recall bias. The objective of this study was to verify the predictive value of pre-stroke ADL with respect to ADL decline in a large prospective cohort of community dwelling older subjects with known vascular risk factors or vascular disease, thereby minimizing selection and recall bias.

Associations Between Type and Timing of Physical Activity and Sedentary Behavior With Mental Health in Adolescents and Young Adults.

Background: This cross-sectional study analyzed the association of leisure-time physical activity (PA) and sedentary behavior (SB), nonleisure PA and SB, and total PA and SB in different time segments of the day with mental health among Dutch adolescents and young adults.

Methods: A total of 881 participants aged 16-25 years completed an online survey. Mental health was assessed using the Mental Health Inventory-5, and participants also reported sex, age, and income.

Accurate holographic light potentials using pixel crosstalk modelling.

Arbitrary light potentials have proven to be a valuable and versatile tool in many quantum information and quantum simulation experiments with ultracold atoms. Using a phase-modulating spatial light modulator (SLM), we generate arbitrary light potentials holographically with measured efficiencies between 15 and 40% and an accuracy of [Formula: see text] root-mean-squared error. Key to the high accuracy is the modelling of pixel crosstalk of the SLM on a sub-pixel scale which is relevant especially for large light potentials.

MOGS-CDG: Quantitative analysis of the diagnostic Glc Man tetrasaccharide and clinical spectrum of six new cases.

Congenital disorders of glycosylation (CDG) are a clinically and biochemically heterogeneous subgroup of inherited metabolic disorders. Most CDG with abnormal N-glycosylation can be detected by transferrin screening, however, MOGS-CDG escapes this routine screening. Combined with the clinical heterogeneity of reported cases, diagnosing MOGS-CDG can be challenging.

Electronic Brainstorming With a Chatbot Partner: A Good Idea Due to Increased Productivity and Idea Diversity.

Brainstorming is a creative technique that fosters collaboration to enhance idea generation. The occurrence of evaluation apprehension, a fear of being evaluated negatively by others, however, can stymy brainstorming. How the advantages of collaboration can be leveraged while evaluation apprehension is prevented is an open scientific and practical problem.

"Don't Gamble With Children's Rights"-How Behavioral Design Impacts the Right of Children to a Playful and Healthy Game Environment.

Gaming is an important pastime for young people to relax, socialize and have fun, but also to be challenged, show creativity and work together to achieve goals. The design of games can have an impact on their behavior. With the changing revenue models of games, we see that game design is increasingly taking forms that do not always have a positive impact on children and may interfere with, or even violate, children's rights.

International school-related sedentary behaviour recommendations for children and youth.

Background: Existing sedentary behaviour guidelines for children and youth target overall sedentary behaviour and recreational screen time, without any specific recommendations regarding school-related sedentary behaviours (i.e., sedentary behaviours performed during the school day, or within the influence of school).

Floquet Solitons and Dynamics of Periodically Driven Matter Waves with Negative Effective Mass.

We experimentally study the dynamics of weakly interacting Bose-Einstein condensates of cesium atoms in a 1D optical lattice with a periodic driving force. After a sudden start of the driving, we observe the formation of stable wave packets at the center of the first Brillouin zone (BZ) in momentum space, and we interpret these as Floquet solitons in periodically driven systems. The wave packets become unstable when we add a trapping potential along the lattice direction, leading to a redistribution of atoms within the BZ.

The influence of pain catastrophizing and central sensitization on the reported pain after hip arthroscopy.

Purpose: This study was conducted to investigate whether the pain catastrophizing scale (PCS) and the central sensitization inventory (CSI) are predictive factors for the reported pain after hip arthroscopy.

Methods: A total of 37 patients undergoing hip arthroscopy for femoroacetabular impingement syndrome and labral tears were prospectively enrolled. All patients completed the PCS and CSI before hip arthroscopy.

Brainstorming With a Social Robot Facilitator: Better Than Human Facilitation Due to Reduced Evaluation Apprehension?

Brainstorming is a creative technique used to support productivity and creativity during the idea generation phase of an innovation process. In professional practice, a facilitator structures, regulates, and motivates those behaviors of participants that help maintain productivity and creativity during a brainstorm. Emerging technologies, such as social robots, are being developed to support or even automate the facilitator's role.

Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy.

BackgroundPyridoxine-dependent epilepsy (PDE-ALDH7A1) is an inborn error of lysine catabolism that presents with refractory epilepsy in newborns. Biallelic ALDH7A1 variants lead to deficiency of α-aminoadipic semialdehyde dehydrogenase/antiquitin, resulting in accumulation of piperideine-6-carboxylate (P6C), and secondary deficiency of the important cofactor pyridoxal-5'-phosphate (PLP, active vitamin B6) through its complexation with P6C. Vitamin B6 supplementation resolves epilepsy in patients, but intellectual disability may still develop.

The relationship between mental well-being and dysregulated gaming: a specification curve analysis of core and peripheral criteria in five gaming disorder scales.

Gaming disorder (also known as dysregulated gaming) has received significant research and policy attention based on concerns that certain patterns of play are associated with decreased mental well-being and/or functional impairment. In this study, we use specification curve analysis to examine analytical flexibility and the strength of the relationship between dysregulated gaming and well-being in the form of general mental health, depressive mood and life satisfaction. Dutch and Flemish gamers ( = 424) completed an online survey containing five unique dysregulated gaming measures (covering nine scale variants) and three well-being measures.

Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism.

The identification of disease biomarkers plays a crucial role in developing diagnostic strategies for inborn errors of metabolism and understanding their pathophysiology. A primary metabolite that accumulates in the inborn error phenylketonuria is phenylalanine, however its levels do not always directly correlate with clinical outcomes. Here we combine infrared ion spectroscopy and NMR spectroscopy to identify the Phe-glucose Amadori rearrangement product as a biomarker for phenylketonuria.

Evaluation of cyclooxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry.

Introduction: Obesity is associated with adipose tissue inflammation which in turn drives insulin resistance and the development of type 2 diabetes. Oxylipins are a collection of lipid metabolites, subdivided in different classes, which are involved in inflammatory cascades. They play important roles in regulating adipose tissue homeostasis and inflammation and are therefore putative biomarkers for obesity-associated adipose tissue inflammation and the subsequent risk of type 2 diabetes onset.

Factors Associated With Sleep Quality in Patients With Chronic Widespread Pain Attending Multidisciplinary Treatment.

Purpose: (1) To investigate the prevalence of poor sleep quality and (2) to explore the associations between clinical, cognitive, and emotional factors and quality of sleep in patients with chronic widespread pain (CWP) receiving multidisciplinary treatment.

Method: Baseline data were used from 163 patients with CWP referred for multidisciplinary treatment. Linear regression models were used to assess the relationship of clinical (pain, fatigue, pain interference, and disability), emotional (anxiety, depression, and psychological distress), and cognitive factors (catastrophizing, acceptance, self-efficacy, kinesiophobia and illness beliefs) with sleep quality, as measured using the Pittsburgh Sleep Quality Index.

The Predictive Creative Mind: A First Look at Spontaneous Predictions and Evaluations During Idea Generation.

Idea generation, the process of creating and developing candidate solutions that when implemented can solve ill-defined and complex problems, plays a pivotal role in creativity and innovation. The algorithms that underlie classical evolutionary, cognitive, and process models of idea generation, however, appear too inefficient to effectively help solve the ill-defined and complex problems for which one would engage in idea generation. To address this, these classical models have recently been redesigned as forward models, drawing heavily on the "predictive mind" literature.

-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate.

Background: Mutations in isocitrate dehydrogenase 1 () occur in various types of cancer and induce metabolic alterations resulting from the neomorphic activity that causes production of -2-hydroxyglutarate (2-HG) at the expense of α-ketoglutarate (α-KG) and NADPH. To overcome metabolic stress induced by these alterations, -mutated ( ) cancers utilize rescue mechanisms comprising pathways in which glutaminase and glutamate dehydrogenase (GLUD) are involved. We hypothesized that inhibition of glutamate processing with the pleiotropic GLUD-inhibitor epigallocatechin-3-gallate (EGCG) would not only hamper 2-HG production, but also decrease NAD(P)H and α-KG synthesis in cancers, resulting in increased metabolic stress and increased sensitivity to radiotherapy.